Family main features
TYRO3, a member of the TAM receptor tyrosine kinase family, plays a critical role in various cellular processes, including cell survival, proliferation, and immune regulation. The TAM family consists of three receptors: TYRO3, AXL, and MERTK, all of which are characterized by their involvement in modulating immune responses and maintaining tissue homeostasis. TYRO3 is encoded by the TYRO3 gene located on chromosome 15q15 in humans and is widely expressed in tissues such as the brain, reproductive organs, and the immune system. Understanding the structural and functional properties of TYRO3 is crucial for elucidating its roles in health and disease.
TYRO3 is a type I transmembrane protein comprising several distinct domains:
TYRO3 is one of the three members of the TAM receptor family, alongside AXL and MERTK. These receptors share structural similarities but have distinct functional roles and expression patterns:
TYRO3 functions through its interaction with ligands such as GAS6 and protein S, leading to receptor dimerization and autophosphorylation. This activation initiates several downstream signaling pathways, including:
TYRO3 is essential for various physiological processes:
Dysregulation of TYRO3 is associated with various pathological conditions:
TYRO3 is a crucial member of the TAM receptor tyrosine kinase family, with significant roles in neuroprotection, immune regulation, and reproductive health. Its structure, comprising extracellular Ig-like and FNIII domains, a transmembrane domain, and an intracellular kinase domain, enables it to mediate essential signaling pathways. Dysregulation of TYRO3 is linked to cancer, autoimmune diseases, and neurological disorders, highlighting its importance in maintaining cellular and tissue homeostasis. As research advances, targeting TYRO3 may offer therapeutic potential for various diseases, emphasizing the need for a comprehensive understanding of its biological functions and clinical implications.
TYRO3 protein tyrosine kinase (TYRO3)
BYK,Dtk,RSE,Rek,Sky,Tif,Etk-2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con TYRO3 protein tyrosine kinase
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TYRO3 | abx385503 | Human Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q06418 | RUO |
FineTest | TYRO3 | EH15480 | Human TYRO3 (Tyrosine-protein kinase receptor TYRO3) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q06418 | RUO | ||
Abbexa | TYRO3 | abx390809 | Mouse Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | P55144 | RUO |
Abbexa | TYRO3 | abx392088 | Rat Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | P55146 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TYRO3 | abx302282 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q06418 | RUO | |
Abbexa | TYRO3 | abx033611 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q06418 | RUO | |
Abbexa | TYRO3 | abx012308 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA, IF/ICC | 362.5 | 100 µl | Q06418 | RUO | |
Abbexa | TYRO3 | abx015715 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA | 362.5 | 100 µl | Q06418 | RUO | |
Abbexa | TYRO3 | abx316070 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Biotin | ELISA | 162.5 | 20 µg | Q06418 | RUO | |
Abbexa | TYRO3 | abx316068 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody (HRP) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | HRP | ELISA | 162.5 | 20 µg | Q06418 | RUO | |
Abbexa | TYRO3 | abx316069 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody (FITC) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | FITC | 162.5 | 20 µg | Q06418 | RUO | ||
Abbexa | TYRO3 | abx016061 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA, IF/ICC | 362.5 | 100 µl | Q06418 | RUO | |
Abbexa | TYRO3 | abx033610 | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q06418 | RUO |
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