Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody
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Description
Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody is a Rabbit polyclonal antibody for the detection of Human Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q06418 |
| Gene ID | 7301 |
| NCBI Accession | NP_001317193.1 |
| Alias | BYK,Dtk,RSE,Rek,Sky,Tif,Etk-2 |
| Background | Antibody anti-TYRO3 |
| Status | RUO |
Descripción
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Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody
Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.
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Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody
TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky.Entrez Protein: NP_006284.It belongs to the Tyr protein kinase family (AXL/UFO subfamily).The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse (also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl).Two distinct isoforms of Rse, designated Brt and Etk-2, have been described.Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence.It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface.Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence.Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
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