Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody
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Description
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q06418 |
| Alias | BYK,Dtk,RSE,Rek,Sky,Tif,Etk-2 |
| Background | Antibody anti-TYRO3 |
| Status | RUO |
Descripción
TYRO3, a member of the TAM receptor tyrosine kinase family, plays a critical role in various cellular processes, including cell survival, proliferation, and immune regulation. The TAM family consists of three receptors: TYRO3, AXL, and MERTK, all of which are characterized by their involvement in modulating immune responses and maintaining tissue homeostasis. TYRO3 is encoded by the TYRO3 gene located on chromosome 15q15 in humans and is widely expressed in tissues such as the brain, reproductive organs, and the immune system. Understanding the structural and functional properties of TYRO3 is crucial for elucidating its roles in health and disease.
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Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.
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TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky.Entrez Protein: NP_006284.It belongs to the Tyr protein kinase family (AXL/UFO subfamily).The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse (also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl).Two distinct isoforms of Rse, designated Brt and Etk-2, have been described.Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence.It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface.Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence.Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
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