Family main features
TRAF family member-associated NF-kappa-B activator (TANK) is a pivotal adaptor protein involved in the regulation of NF-κB signaling pathways. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a critical transcription factor that controls the expression of genes involved in immune and inflammatory responses, cell survival, and proliferation. TANK functions as a scaffold protein that modulates the activity of TRAF (TNF receptor-associated factor) proteins, which are essential mediators in NF-κB signaling. By interacting with TRAF proteins, TANK helps in regulating the activation and inhibition of NF-κB pathways, thereby influencing immune responses and cellular stress reactions. Dysregulation of TANK is implicated in various pathological conditions, including autoimmune diseases, cancers, and chronic inflammatory disorders.
TANK is composed of several functional domains:
TANK is classified as an adaptor protein within the NF-κB signaling pathway. While there are no specific subtypes of TANK, it interacts with various TRAF family members (such as TRAF2, TRAF3, and TRAF5) and other signaling molecules, highlighting its versatile role in different signaling contexts.
TANK plays several critical roles in cellular processes:
Dysregulation of TANK is associated with various diseases:
TANK (TRAF family member-associated NF-kappa-B activator) is a crucial adaptor protein in the regulation of NF-κB signaling pathways, impacting immune responses, cell survival, and inflammation. It interacts with TRAF proteins and other signaling molecules through its coiled-coil and phosphorylation-rich domains, facilitating the assembly and regulation of NF-κB signaling complexes. Dysregulation of TANK is linked to autoimmune diseases, cancers, and chronic inflammatory disorders, underscoring its importance in maintaining cellular homeostasis and its potential as a therapeutic target. Understanding the precise mechanisms of TANK function and regulation offers valuable insights into the treatment of these diseases.
TRAF family member-associated NF-kappa-B activator(TANK)
TANK,I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con TANK - TRAF family member-associated NF-kappa-B activator
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 14 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TANK | abx385480 | Human TRAF family member-associated NF-kappa-B activator (TANK) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q92844 | RUO |
Abbexa | TANK | abx390758 | Mouse TRAF family member-associated NF-kappa-B activator (TANK) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | P70347 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | TANK | abx314936 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody (FITC) | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | FITC | 162.5 | 20 µg | Q92844 | RUO | ||
Abbexa | TANK | abx128044 | TRAF Family Member Associated NFKB Activator (TANK) Antibody | Human | Polyclonal | Rabbit | TRAF Family Member Associated NFKB Activator (TANK) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TANK | abx302188 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q92844 | RUO | |
Abbexa | TANK | abx314935 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody (HRP) | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | HRP | ELISA | 162.5 | 20 µg | Q92844 | RUO | |
Abbexa | TANK | abx032645 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | Q92844 | RUO | |
Abbexa | TANK | abx314937 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody (Biotin) | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | Biotin | ELISA | 162.5 | 20 µg | Q92844 | RUO | |
Abbexa | TANK | abx329285 | TRAF Family Member Associated NFKB Activator (TANK) Antibody | Human | Polyclonal | Rabbit | TRAF Family Member Associated NFKB Activator (TANK) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | Q92844 | RUO | |
Abbexa | TANK | abx005187 | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody | Human | Polyclonal | Rabbit | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) | Unconjugated | WB | 175 | 20 µl | Q92844 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TANK | abx261705 | TRAF Family Member-Associated NF-kappa-B Activator (TANK) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q92844 | RUO | ||
FineTest | TANK | P6337 | Recombinant Human TANK | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q92844 | RUO | ||
Abbexa | TANK | abx260634 | TRAF Family Member-Associated NF-kappa-B Activator (TANK) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 10 µg | Q92844 | RUO | ||
Abbexa | TANK | abx166995 | Human TRAF Family Member Associated NFKB Activator (TANK) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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