TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody
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Description
TANK Antibody is a Rabbit Polyclonal against TANK.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | TRAF Family Member-Associated NF-Kappa-B Activator (TANK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92844 |
| Gene ID | 10010 |
| NCBI Accession | NP_001186064.1, NM_001199135.1 |
| OMIM | 603893 |
| Alias | TANK,I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator |
| Background | Antibody anti-TANK |
| Status | RUO |
Descripción
TRAF family member-associated NF-kappa-B activator (TANK) is an adaptor protein involved in the regulation of NF-kappa-B signaling pathways, which play crucial roles in immune and inflammatory responses, cell survival, and apoptosis. TANK functions as a scaffold protein that interacts with members of the TRAF family, such as TRAF2, TRAF3, and TRAF6, to modulate the activation of kinases like IKK (I-kappa-B kinase), which are critical for NF-kappa-B activation. It acts as a negative regulator in certain contexts by inhibiting overactivation of signaling pathways, thereby preventing excessive inflammatory responses. TANK is also implicated in antiviral immunity, as it participates in the regulation of type I interferon production through interactions with signaling components like TBK1 and IKKε. Dysregulation of TANK expression or mutations can contribute to immune-related disorders, including autoimmune diseases and chronic inflammatory conditions, where abnormal NF-kappa-B activity is a hallmark. TANK's role extends to maintaining homeostasis in B-cell development and antibody production, further highlighting its importance in adaptive immunity. Additionally, post-translational modifications of TANK, such as ubiquitination and phosphorylation, influence its activity and interactions, ensuring precise control of signaling dynamics in response to cellular and extracellular stimuli.
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TANK Antibody is a Rabbit Polyclonal antibody against TANK. The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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