Recombinant Human TANK
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 1-448 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 49.2 kDa |
| Expression | Recombinant |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Purification | His tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Tested Applications | Western Blot,ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 3-4 weeks |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | Q92844 |
| Alias | TANK,I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator |
| Background | Proteins TANK |
| Status | RUO |
| Note | This product is for research use only. |
TRAF family member-associated NF-kappa-B activator (TANK) is an adaptor protein involved in the regulation of NF-kappa-B signaling pathways, which play crucial roles in immune and inflammatory responses, cell survival, and apoptosis. TANK functions as a scaffold protein that interacts with members of the TRAF family, such as TRAF2, TRAF3, and TRAF6, to modulate the activation of kinases like IKK (I-kappa-B kinase), which are critical for NF-kappa-B activation. It acts as a negative regulator in certain contexts by inhibiting overactivation of signaling pathways, thereby preventing excessive inflammatory responses. TANK is also implicated in antiviral immunity, as it participates in the regulation of type I interferon production through interactions with signaling components like TBK1 and IKKε. Dysregulation of TANK expression or mutations can contribute to immune-related disorders, including autoimmune diseases and chronic inflammatory conditions, where abnormal NF-kappa-B activity is a hallmark. TANK's role extends to maintaining homeostasis in B-cell development and antibody production, further highlighting its importance in adaptive immunity. Additionally, post-translational modifications of TANK, such as ubiquitination and phosphorylation, influence its activity and interactions, ensuring precise control of signaling dynamics in response to cellular and extracellular stimuli.
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