Family main features
Toll-interacting protein (TOLLIP) is an essential adaptor protein that plays a significant role in the regulation of Toll-like receptor (TLR) signaling pathways. TLRs are a class of proteins that recognize pathogen-associated molecular patterns (PAMPs) and initiate innate immune responses. TOLLIP is involved in modulating the immune response to prevent excessive inflammation, which can lead to tissue damage and chronic inflammatory diseases. It acts as a negative regulator of TLR signaling, ensuring that immune responses are appropriately controlled. This protein has been the subject of extensive research due to its critical role in maintaining immune homeostasis and its potential implications in various diseases, including autoimmune disorders, infections, and cancers.
TOLLIP comprises several functional domains that facilitate its role in TLR signaling:
TOLLIP is classified within the family of adaptor proteins involved in TLR signaling. There are no specific subtypes of TOLLIP, but it functions in concert with various other adaptor proteins and signaling molecules to regulate immune responses. Its interactions with different proteins, such as IRAK1, IRAK4, and Tom1, highlight its versatile role in modulating TLR pathways.
TOLLIP serves several vital functions in cellular signaling and immune response:
Dysregulation or mutations in TOLLIP are linked to various diseases:
Toll-interacting protein (TOLLIP) is a crucial adaptor protein that negatively regulates Toll-like receptor (TLR) signaling, ensuring balanced immune responses and preventing excessive inflammation. TOLLIP's structure includes a C2 domain, a Tom1 binding domain, and a C-terminal domain, facilitating its interactions with phospholipids and various signaling proteins. Its functions are vital for immune homeostasis, endosomal sorting, and responses to infections. Dysregulation of TOLLIP is implicated in autoimmune diseases, chronic inflammatory conditions, infections, and cancer, highlighting its importance in health and disease. Understanding TOLLIP's mechanisms offers valuable insights into potential therapeutic targets for these conditions.
Toll interacting protein (TOLLIP)
TOLLIP, IL-1RAcPIP, toll interacting protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con TOLLIP - Toll interacting protein
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Esta página contiene 31 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TOLLIP | abx555363 | Chicken Toll-Interacting Protein (TOLLIP) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5ZK05 | RUO | ||
Abbexa | TOLLIP | abx555805 | Cow Toll-Interacting Protein (TOLLIP) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q2LGB5 | RUO | ||
Abbexa | TOLLIP | abx153350 | Human Toll Interacting Protein (TOLLIP) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | TOLLIP | abx493908 | Human Toll Interacting Protein (TOLLIP) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.058 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TOLLIP | abx556116 | Mouse Toll-Interacting Protein (TOLLIP) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 32 pg/ml | 687.5 | 96 tests | Q9QZ06 | RUO |
Abbexa | TOLLIP | abx556254 | Rat Toll-Interacting Protein (TOLLIP) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.9 pg/ml | 687.5 | 96 tests | A2RUW1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TOLLIP | FNab10220 | anti- TOLLIP antibody | human | polyclonal | Rabbit | Toll-interacting protein | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | Q9H0E2 | RUO | |
FineTest | TOLLIP | FNab08854 | anti- TOLLIP antibody | human | polyclonal | Rabbit | toll interacting protein | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx145329 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | TOLLIP | abx376462 | Toll Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC, IF/ICC | 225 | 50 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx301816 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx015208 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | WB, IHC | 43.75 | 10 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx315511 | Toll-Interacting Protein (TOLLIP) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Biotin | ELISA | 162.5 | 20 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx315509 | Toll-Interacting Protein (TOLLIP) Antibody (HRP) | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | HRP | ELISA | 162.5 | 20 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx031560 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx324696 | Toll Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx315510 | Toll-Interacting Protein (TOLLIP) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | FITC | 162.5 | 20 µg | Q9H0E2 | RUO | ||
Abbexa | TOLLIP | abx102695 | Toll Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll Interacting Protein (TOLLIP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx174835 | Toll Interacting Protein (TOLLIP) Antibody | Human | Monoclonal | Mouse | Toll Interacting Protein (TOLLIP) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | TOLLIP | abx137443 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Monoclonal | Mouse | Toll-Interacting Protein (TOLLIP) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | TOLLIP | abx146557 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx116122 | Toll Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx238854 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx001814 | Toll-Interacting Protein (TOLLIP) Antibody | Human | Polyclonal | Rabbit | Toll-Interacting Protein (TOLLIP) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q9H0E2 | RUO | |
Abbexa | TOLLIP | abx102696 | Toll Interacting Protein (TOLLIP) Antibody | Mouse | Polyclonal | Rabbit | Toll Interacting Protein (TOLLIP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | TOLLIP | abx415341 | Toll-Interacting Protein (TOLLIP) Antibody | Mouse | Monoclonal | Rat | Toll-Interacting Protein (TOLLIP) | Unconjugated | WB, IP | 512.5 | 50 µg | Q9QZ06 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TOLLIP | abx069355 | Mouse Toll Interacting Protein (TOLLIP) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9QZ06 | RUO |
Abbexa | TOLLIP | abx262822 | Toll Interacting Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9H0E2 | RUO | ||
FineTest | TOLLIP | P6636 | Recombinant Human Tollip | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9H0E2 | RUO | ||
Abbexa | TOLLIP | abx069354 | Human Toll Interacting Protein (TOLLIP) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9H0E2 | RUO |
FineTest | TOLLIP | P0205 | Recombinant Human TOLLIP | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q9H0E2 | RUO |
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