Mouse Toll Interacting Protein (TOLLIP) Protein

Este producto es parte de TOLLIP - Toll interacting protein
Mouse Toll Interacting Protein (TOLLIP) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein TOLLIP

proveedor

Abbexa

reference

abx069355

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Toll Interacting Protein (TOLLIP) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

TOLLIP is a negative regulator of Toll-like receptor (TLR) signaling, controlling inflammatory responses by inhibiting downstream activation of NF-κB and MAPK pathways. It functions as an adaptor protein that binds to TLRs and signaling intermediates, such as IRAK1 and TRAF6, to dampen excessive cytokine production and inflammatory responses during pathogen recognition. TOLLIP also plays a role in endosomal trafficking and autophagy, regulating receptor turnover and degradation to maintain immune homeostasis. It is widely expressed in immune cells, epithelial tissues, and organs like the liver and lungs, where it prevents chronic inflammation and excessive immune activation. Dysregulation or reduced expression of TOLLIP is associated with inflammatory diseases, autoimmune disorders, and increased susceptibility to infections. Knockdown studies reveal hyperactivated TLR signaling, elevated cytokine production, and impaired immune tolerance, highlighting its role as a key regulator of TLR signaling, inflammation, and immune homeostasis.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Toll Interacting Protein (TOLLIP)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln19-Glu254 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TOLLIP


dry ice

No


availability

Shipped within 5-7 working days.


alias

TOLLIP, IL-1RAcPIP, toll interacting protein


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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