Toll Interacting Protein (TOLLIP) Antibody
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935106861
info@markelab.com
Precio
819€ (1 ml)
Antibody anti-TOLLIP
proveedor
Abbexareference
abx174835Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
This product is currently in development. The lead time for this product may be several months. Please contact us at
Background
TOLLIP is a negative regulator of Toll-like receptor (TLR) signaling, controlling inflammatory responses by inhibiting downstream activation of NF-κB and MAPK pathways. It functions as an adaptor protein that binds to TLRs and signaling intermediates, such as IRAK1 and TRAF6, to dampen excessive cytokine production and inflammatory responses during pathogen recognition. TOLLIP also plays a role in endosomal trafficking and autophagy, regulating receptor turnover and degradation to maintain immune homeostasis. It is widely expressed in immune cells, epithelial tissues, and organs like the liver and lungs, where it prevents chronic inflammation and excessive immune activation. Dysregulation or reduced expression of TOLLIP is associated with inflammatory diseases, autoimmune disorders, and increased susceptibility to infections. Knockdown studies reveal hyperactivated TLR signaling, elevated cytokine production, and impaired immune tolerance, highlighting its role as a key regulator of TLR signaling, inflammation, and immune homeostasis.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Toll Interacting Protein (TOLLIP)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by Protein A and Protein G affinity chromatography.
recommended dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
TOLLIP
dry ice
No
availability
Please enquire.
alias
TOLLIP, IL-1RAcPIP, toll interacting protein
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