Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity(PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates(PubMed:25042851).
Primary Antibodies
polyclonal
human,mouse,rat
toll interacting protein
Rabbit
IgG
Unconjugated
liquid
ELISA, WB, IHC, IF
30 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:100
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
TOLLIP
TOLLIP, IL-1RAcPIP, toll interacting protein
This product is for research use only.
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recr...
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