Family main features
STUB1, also known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial E3 ubiquitin ligase that plays a significant role in protein quality control by interacting with chaperones HSP70 and HSP90. This interaction facilitates the ubiquitination and subsequent proteasomal degradation of misfolded or damaged proteins. STUB1 was identified as a protein that not only assists in chaperone-mediated protein folding but also in the regulation of protein turnover, making it essential for maintaining cellular homeostasis. Dysregulation of STUB1 is linked to various pathological conditions, including neurodegenerative diseases, cancer, and cardiac disorders.
STUB1 is composed of distinct domains that enable its function:
STUB1 belongs to the U-box family of E3 ubiquitin ligases, characterized by the presence of a U-box domain that confers ubiquitin ligase activity. There are no known subtypes of STUB1, but it is part of a larger network of proteins involved in protein quality control and ubiquitination.
STUB1 plays several key roles in cellular physiology:
Aberrations in STUB1 function are associated with multiple diseases:
STUB1 (CHIP) is a pivotal E3 ubiquitin ligase and co-chaperone protein essential for maintaining protein quality control within cells. Comprising TPR and U-box domains, STUB1 interacts with chaperones like HSP70 and HSP90 to identify and tag misfolded proteins for degradation. It plays a significant role in stress response, cell signaling, and apoptosis. Dysregulation of STUB1 is implicated in a variety of diseases, including neurodegenerative disorders, cancer, and cardiac diseases. Understanding the mechanisms of STUB1 function and regulation provides insights into potential therapeutic strategies for these conditions.
STIP1 Homology And U-Box Containing Protein 1 (STUB1)
STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein,E3 ubiquitin-protein ligase CHIP
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con STUB1 - STIP1 Homology And U-Box Containing Protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 24 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | STUB1 | abx555366 | Chicken STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5ZHY5 | RUO | ||
FineTest | STUB1 | EH3833 | Human STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q9UNE7 | RUO | ||
Abbexa | STUB1 | abx253227 | Human STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 525 | 96 tests | Q9UNE7 | RUO |
FineTest | STUB1 | EM1381 | Mouse STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9WUD1 | RUO | ||
Abbexa | STUB1 | abx254439 | Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | Q9WUD1 | RUO |
Abbexa | STUB1 | abx154716 | Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 700 | 96 tests | RUO | |
Abbexa | STUB1 | abx495878 | Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) CLIA Kit | Mouse | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 837.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | STUB1 | FNab08357 | anti- STUB1 antibody | human | polyclonal | Rabbit | STIP1 homology and U-box containing protein 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx316670 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (FITC) | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | FITC | 162.5 | 20 µg | Q9UNE7 | RUO | ||
Abbexa | STUB1 | abx026635 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, FCM | 281.25 | 80 µl | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx018351 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Monoclonal | Mouse | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB | 300 | 100 µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx316671 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (Biotin) | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Biotin | ELISA | 162.5 | 20 µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx316669 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (HRP) | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | HRP | ELISA | 162.5 | 20 µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx430610 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Goat | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | STUB1 | abx025112 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx318798 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx117049 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx238357 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9UNE7 | RUO | |
Abbexa | STUB1 | abx037852 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | STUB1 | abx126673 | STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody | Human | Polyclonal | Rabbit | STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Unconjugated | WB, IF/ICC, IP | 175 | 20 µl | Q9UNE7 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | STUB1 | P6987 | Recombinant Human STUB1 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9UNE7 | RUO | ||
FineTest | STUB1 | P2392 | Recombinant Human STUB1 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q9UNE7 | RUO | ||
Abbexa | STUB1 | abx655146 | Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | STUB1 | abx260418 | STIP1 Homology and U-Box Containing Protein 1 Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 10 µg | Q9UNE7 | RUO |
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