STUB1 - STIP1 Homology And U-Box Containing Protein | Elisa - Clia - Antibody - Protein

Family main features

Background

STUB1, also known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial E3 ubiquitin ligase that plays a significant role in protein quality control by interacting with chaperones HSP70 and HSP90. This interaction facilitates the ubiquitination and subsequent proteasomal degradation of misfolded or damaged proteins. STUB1 was identified as a protein that not only assists in chaperone-mediated protein folding but also in the regulation of protein turnover, making it essential for maintaining cellular homeostasis. Dysregulation of STUB1 is linked to various pathological conditions, including neurodegenerative diseases, cancer, and cardiac disorders.


Protein Structure

STUB1 is composed of distinct domains that enable its function:

  • TPR (Tetratricopeptide Repeat) Domain: Located at the N-terminus, this domain facilitates interaction with HSP70 and HSP90 chaperones.
  • U-Box Domain: Located at the C-terminus, this domain has E3 ubiquitin ligase activity, essential for tagging substrate proteins with ubiquitin for proteasomal degradation.
  • Coiled-Coil Domain: Provides structural stability and facilitates dimerization, which is necessary for its functional activity.


Classification and Subtypes

STUB1 belongs to the U-box family of E3 ubiquitin ligases, characterized by the presence of a U-box domain that confers ubiquitin ligase activity. There are no known subtypes of STUB1, but it is part of a larger network of proteins involved in protein quality control and ubiquitination.


Function and Biological Significance

STUB1 plays several key roles in cellular physiology:

  • Protein Quality Control: By interacting with chaperones, STUB1 assists in the identification and ubiquitination of misfolded or damaged proteins, targeting them for degradation by the proteasome.
  • Regulation of Chaperone Function: STUB1 modulates the activity of HSP70 and HSP90, influencing their ability to fold client proteins.
  • Stress Response: Under stress conditions, STUB1 expression is upregulated to enhance the cell's capacity to manage misfolded proteins.
  • Cell Signaling and Apoptosis: STUB1 regulates various signaling pathways by targeting specific signaling proteins for degradation, thus influencing cell growth, differentiation, and apoptosis.


Clinical Issues

Aberrations in STUB1 function are associated with multiple diseases:

  • Neurodegenerative Diseases: Mutations or dysfunctions in STUB1 are linked to disorders such as Alzheimer's, Parkinson's, and spinocerebellar ataxias, where the accumulation of misfolded proteins is a common pathological feature.
  • Cancer: STUB1 can act as a tumor suppressor by promoting the degradation of oncogenic proteins. Altered STUB1 expression or activity can contribute to tumorigenesis.
  • Cardiac Disorders: STUB1 is involved in cardiac proteostasis, and its dysfunction can lead to cardiac hypertrophy and heart failure.
  • Inflammatory Diseases: STUB1 influences immune responses and inflammation by regulating the turnover of signaling proteins involved in these processes.


Summary

STUB1 (CHIP) is a pivotal E3 ubiquitin ligase and co-chaperone protein essential for maintaining protein quality control within cells. Comprising TPR and U-box domains, STUB1 interacts with chaperones like HSP70 and HSP90 to identify and tag misfolded proteins for degradation. It plays a significant role in stress response, cell signaling, and apoptosis. Dysregulation of STUB1 is implicated in a variety of diseases, including neurodegenerative disorders, cancer, and cardiac diseases. Understanding the mechanisms of STUB1 function and regulation provides insights into potential therapeutic strategies for these conditions.


STUB1 Recommended name:

STIP1 Homology And U-Box Containing Protein 1 (STUB1)

Aliases for STUB1

STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein,E3 ubiquitin-protein ligase CHIP 

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con STUB1 - STIP1 Homology And U-Box Containing Protein

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaSTUB1abx555366Chicken STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA KitChickenTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ5ZHY5RUO
FineTestSTUB1EH3833Human STUB1(E3 ubiquitin-protein ligase CHIP) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody31.25-2000pg/ml96TQ9UNE7RUO
AbbexaSTUB1abx253227Human STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml54696 testsQ9UNE7RUO
FineTestSTUB1EM1381Mouse STUB1(E3 ubiquitin-protein ligase CHIP) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.156-10ng/ml96TQ9WUD1RUO
AbbexaSTUB1abx154716Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA KitMouseTissue homogenates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml72896 testsRUO
AbbexaSTUB1abx254439Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml0.1 ng/ml54696 testsQ9WUD1RUO
AbbexaSTUB1abx495878Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) CLIA KitMouseTissue homogenates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.059 ng/ml87196 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestSTUB1FNab08357anti- STUB1 antibodyhumanpolyclonalRabbitSTIP1 homology and U-box containing protein 1IgGUnconjugatedELISA, WB, IHC100µgQ9UNE7RUO
AbbexaSTUB1abx026635STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, FCM281.2580 µlQ9UNE7RUO
AbbexaSTUB1abx018351STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanMonoclonalMouseSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB300100 µgQ9UNE7RUO
AbbexaSTUB1abx025112STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, IHC281.2580 µlQ9UNE7RUO
AbbexaSTUB1abx316671STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (Biotin)HumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)BiotinELISA162.520 µgQ9UNE7RUO
AbbexaSTUB1abx316669STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (HRP)HumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)HRPELISA162.520 µgQ9UNE7RUO
AbbexaSTUB1abx430610STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalGoatSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedP-ELISA, WB387.5200 µlRUO
AbbexaSTUB1abx316670STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody (FITC)HumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)FITC162.520 µgQ9UNE7RUO
AbbexaSTUB1abx037852STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaSTUB1abx117049STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, IHC450100 µlQ9UNE7RUO
AbbexaSTUB1abx126673STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedWB, IF/ICC, IP17520 µlQ9UNE7RUO
AbbexaSTUB1abx238357STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, IHC350100 µgQ9UNE7RUO
AbbexaSTUB1abx318798STIP1 Homology And U-Box Containing Protein 1 (STUB1) AntibodyHumanPolyclonalRabbitSTIP1 Homology And U-Box Containing Protein 1 (STUB1)UnconjugatedELISA, WB, IHC, IF/ICC162.520 µgQ9UNE7RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
FineTestSTUB1P6987Recombinant Human STUB1HumanRecombinantE.ColiWestern Blot,ELISA50μgQ9UNE7RUO
AbbexaSTUB1abx260418STIP1 Homology and U-Box Containing Protein 1 ProteinHumanRecombinantUnconjugatedSDS-PAGE22510 µgQ9UNE7RUO
AbbexaSTUB1abx655146Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE18001 mgRUO
FineTestSTUB1P2392Recombinant Human STUB1HumanRecombinantE.ColiWestern Blot, ELISA50μgQ9UNE7RUO

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