Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit

Este producto es parte de STUB1 - STIP1 Homology And U-Box Containing Protein
Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit

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935106861

info@markelab.com

Precio

700€ (96 tests)

Elisa Kits STUB1

proveedor

Abbexa

reference

abx154716

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of STIP1 Homology And U-Box Containing Protein 1 (STUB1)No significant cross-reactivity or interference between STIP1 Homology And U-Box Containing Protein 1 (STUB1) and analogues was observed.


Background

STUB1, also known as CHIP (C-terminus of Hsc70-interacting protein), is a co-chaperone protein and E3 ubiquitin ligase that regulates protein homeostasis by linking the molecular chaperones HSP70 and HSP90 to the ubiquitin-proteasome system. STUB1 promotes the ubiquitination and degradation of misfolded, damaged, or surplus proteins, ensuring proper protein quality control and cellular stress responses. It is broadly expressed in tissues and plays a crucial role in proteostasis, particularly under stress conditions where protein misfolding is elevated. STUB1 is also involved in signaling pathways regulating apoptosis, cell survival, and metabolic adaptation by targeting key signaling proteins for degradation. Dysregulation of STUB1 is associated with neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and ataxias, where impaired protein degradation leads to the accumulation of toxic protein aggregates. Knockout studies reveal increased protein misfolding, cellular stress, and neurodegeneration, highlighting its essential role in maintaining proteome integrity and cellular homeostasis.

Características del producto

category

ELISA Kits


immunogen target

STIP1 Homology And U-Box Containing Protein 1 (STUB1)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.06 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Tissue homogenates,Other biological fluids


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

STUB1


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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