Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit
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935106861
info@markelab.com
Precio
700€ (96 tests)
Elisa Kits STUB1
proveedor
Abbexareference
abx154716Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse STIP1 Homology And U-Box Containing Protein 1 (STUB1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of STIP1 Homology And U-Box Containing Protein 1 (STUB1)No significant cross-reactivity or interference between STIP1 Homology And U-Box Containing Protein 1 (STUB1) and analogues was observed.
Background
STUB1, also known as CHIP (C-terminus of Hsc70-interacting protein), is a co-chaperone protein and E3 ubiquitin ligase that regulates protein homeostasis by linking the molecular chaperones HSP70 and HSP90 to the ubiquitin-proteasome system. STUB1 promotes the ubiquitination and degradation of misfolded, damaged, or surplus proteins, ensuring proper protein quality control and cellular stress responses. It is broadly expressed in tissues and plays a crucial role in proteostasis, particularly under stress conditions where protein misfolding is elevated. STUB1 is also involved in signaling pathways regulating apoptosis, cell survival, and metabolic adaptation by targeting key signaling proteins for degradation. Dysregulation of STUB1 is associated with neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and ataxias, where impaired protein degradation leads to the accumulation of toxic protein aggregates. Knockout studies reveal increased protein misfolding, cellular stress, and neurodegeneration, highlighting its essential role in maintaining proteome integrity and cellular homeostasis.
Características del producto
category
ELISA Kits
immunogen target
STIP1 Homology And U-Box Containing Protein 1 (STUB1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
STUB1
dry ice
No
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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