STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody
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935106861
info@markelab.com
Precio
350€ (100 µg)
Antibody anti-STUB1
proveedor
Abbexareference
abx238357Tested Applications
ELISA, WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
STUB1 Antibody is a Rabbit Polyclonal against STUB1.
Background
STUB1, also known as CHIP (C-terminus of Hsc70-interacting protein), is a co-chaperone protein and E3 ubiquitin ligase that regulates protein homeostasis by linking the molecular chaperones HSP70 and HSP90 to the ubiquitin-proteasome system. STUB1 promotes the ubiquitination and degradation of misfolded, damaged, or surplus proteins, ensuring proper protein quality control and cellular stress responses. It is broadly expressed in tissues and plays a crucial role in proteostasis, particularly under stress conditions where protein misfolding is elevated. STUB1 is also involved in signaling pathways regulating apoptosis, cell survival, and metabolic adaptation by targeting key signaling proteins for degradation. Dysregulation of STUB1 is associated with neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and ataxias, where impaired protein degradation leads to the accumulation of toxic protein aggregates. Knockout studies reveal increased protein misfolding, cellular stress, and neurodegeneration, highlighting its essential role in maintaining proteome integrity and cellular homeostasis.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
STIP1 Homology And U-Box Containing Protein 1 (STUB1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purity
≥ 95% (SDS-PAGE)
purification
Purified by immunogen affinity chromatography.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
STUB1
dry ice
No
availability
Shipped within 5-12 working days.
alias
STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein
uniprot id
note
This product is for research use only.
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