STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody

Este producto es parte de STUB1 - STIP1 Homology And U-Box Containing Protein
STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody

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935106861

info@markelab.com

Precio

350€ (100 µg)

Antibody anti-STUB1

proveedor

Abbexa

reference

abx238357

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

STUB1 Antibody is a Rabbit Polyclonal against STUB1.


Background

STUB1, also known as CHIP (C-terminus of Hsc70-interacting protein), is a co-chaperone protein and E3 ubiquitin ligase that regulates protein homeostasis by linking the molecular chaperones HSP70 and HSP90 to the ubiquitin-proteasome system. STUB1 promotes the ubiquitination and degradation of misfolded, damaged, or surplus proteins, ensuring proper protein quality control and cellular stress responses. It is broadly expressed in tissues and plays a crucial role in proteostasis, particularly under stress conditions where protein misfolding is elevated. STUB1 is also involved in signaling pathways regulating apoptosis, cell survival, and metabolic adaptation by targeting key signaling proteins for degradation. Dysregulation of STUB1 is associated with neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and ataxias, where impaired protein degradation leads to the accumulation of toxic protein aggregates. Knockout studies reveal increased protein misfolding, cellular stress, and neurodegeneration, highlighting its essential role in maintaining proteome integrity and cellular homeostasis.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

STIP1 Homology And U-Box Containing Protein 1 (STUB1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purity

≥ 95% (SDS-PAGE)


purification

Purified by immunogen affinity chromatography.


buffer

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

STUB1


dry ice

No


availability

Shipped within 5-12 working days.


alias

STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein


note

This product is for research use only.


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