935106861
info@markelab.com
Precio
Precio a consultar
STUB1, also known as CHIP (C-terminus of Hsc70-interacting protein), is a co-chaperone protein and E3 ubiquitin ligase that regulates protein homeostasis by linking the molecular chaperones HSP70 and HSP90 to the ubiquitin-proteasome system. STUB1 promotes the ubiquitination and degradation of misfolded, damaged, or surplus proteins, ensuring proper protein quality control and cellular stress responses. It is broadly expressed in tissues and plays a crucial role in proteostasis, particularly under stress conditions where protein misfolding is elevated. STUB1 is also involved in signaling pathways regulating apoptosis, cell survival, and metabolic adaptation by targeting key signaling proteins for degradation. Dysregulation of STUB1 is associated with neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and ataxias, where impaired protein degradation leads to the accumulation of toxic protein aggregates. Knockout studies reveal increased protein misfolding, cellular stress, and neurodegeneration, highlighting its essential role in maintaining proteome integrity and cellular homeostasis.
Proteins and Peptides
Human
E.Coli
1-303
E.Coli
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Western Blot,ELISA
50μg
200μg
1mg
33.2 kDa
Recombinant
Greater than 95% by SDS-PAGE gel analyses
His tag
Reconstitute with Sterile distilled water
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
STUB1
3-4 weeks
STUB1,CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1,SCA48,C terminus of HSC70-interacting protein
This product is for research use only.
Precio a consultar
Ver másPrecio a consultar
Ver másE3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates w...
Precio a consultar
Ver más