Family main features
SHB (SH2 domain-containing adapter protein B) is a multifunctional adaptor protein that plays a crucial role in cellular signal transduction. The SHB gene encodes a protein involved in various cellular processes, including proliferation, differentiation, apoptosis, and cytoskeletal organization. SHB is widely expressed in different tissues and cells, including the immune system, endothelial cells, and hematopoietic cells. This protein's function is mediated through its SH2 domain, which facilitates interactions with phosphorylated tyrosine residues on receptor tyrosine kinases and other signaling molecules.
The SHB protein is characterized by the presence of several important domains:
SHB belongs to the family of SH2 domain-containing adaptor proteins, which are involved in mediating protein-protein interactions in signaling pathways. While SHB itself does not have subtypes, it is part of a larger family that includes other related adaptor proteins, such as GRB2, NCK, and CRK, each with distinct yet sometimes overlapping functions in cellular signaling.
SHB is involved in several key cellular processes:
Aberrant expression or mutations in SHB can lead to various pathological conditions:
SHB (SH2 domain-containing adapter protein B) is a critical adaptor protein involved in various cellular processes, including signal transduction, cell proliferation, differentiation, apoptosis, and cytoskeletal organization. It functions primarily through its SH2 domain, which facilitates interactions with phosphorylated tyrosine residues on receptor tyrosine kinases and other proteins. Dysregulation of SHB is associated with multiple diseases, including cancer, immune disorders, and cardiovascular diseases, making it a significant protein in both health and disease. Understanding SHB's molecular mechanisms can provide insights into potential therapeutic targets for these conditions.
SH2 domain-containing adapter protein B (SHB)
SHB, bA3J10.2, SH2 domain containing adaptor protein B
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con SHB - SH2 domain-containing adapter protein B
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 11 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SHB | abx545706 | Human SH2 domain-containing adapter protein B (SHB) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q15464 | RUO | ||
Abbexa | SHB | abx545707 | Mouse SH2 domain-containing adapter protein B (SHB) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6PD21 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SHB | abx104519 | Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody | Human | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B (SHB) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | SHB | abx325651 | Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody | Human | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B (SHB) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q15464 | RUO | |
Abbexa | SHB | abx014877 | Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody | Human | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B (SHB) | Unconjugated | ELISA, WB | 43.75 | 10 µg | Q15464 | RUO | |
Abbexa | SHB | abx325390 | Src Homology 2 Domain Containing Adapter Protein B Phospho-Tyr246 (SHB pY246) Antibody | Human | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B Phospho-Tyr246 (SHB pY246) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q15464 | RUO | |
Abbexa | SHB | abx325389 | Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody | Human | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B (SHB) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q15464 | RUO | |
Abbexa | SHB | abx104520 | Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody | Mouse | Polyclonal | Rabbit | Src Homology 2 Domain Containing Adapter Protein B (SHB) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | SHB | abx030880 | Mouse Shb Antibody | Mouse | Polyclonal | Rabbit | Mouse Shb | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q6PD21 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SHB | abx069164 | Mouse Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q6PD21 | RUO |
Abbexa | SHB | abx069163 | Human Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q15464 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.