Mouse Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein

Este producto es parte de SHB - SH2 domain-containing adapter protein B 
Mouse Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein SHB

proveedor

Abbexa

reference

abx069164

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

SHB is an SH2 domain-containing adaptor protein that mediates signaling downstream of receptor tyrosine kinases, integrins, and cytokine receptors, linking activated receptors to intracellular signaling pathways like PI3K/Akt, MAPK, and VEGF signaling. It plays a critical role in processes such as angiogenesis, cell migration, proliferation, and survival by facilitating interactions between upstream receptors and downstream effectors. SHB is highly expressed in endothelial cells, hematopoietic cells, and pancreatic β-cells, where it regulates vascular development, immune responses, and glucose homeostasis. It is essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and integrin-dependent cytoskeletal reorganization, supporting endothelial cell migration and tubule formation. Dysregulation of SHB has been associated with cancer progression, diabetes, and autoimmune diseases due to its impact on angiogenic signaling, β-cell survival, and immune cell activation. Knockout studies reveal impaired angiogenesis, reduced β-cell mass, and defects in immune system development, underscoring its importance in vascular biology, immune regulation, and metabolic homeostasis.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Src Homology 2 Domain Containing Adapter Protein B (SHB)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser248-Leu484 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

SHB


dry ice

No


availability

Shipped within 5-7 working days.


alias

SHB, bA3J10.2, SH2 domain containing adaptor protein B


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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