Mouse Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein SHB
proveedor
Abbexareference
abx069164Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
SHB is an SH2 domain-containing adaptor protein that mediates signaling downstream of receptor tyrosine kinases, integrins, and cytokine receptors, linking activated receptors to intracellular signaling pathways like PI3K/Akt, MAPK, and VEGF signaling. It plays a critical role in processes such as angiogenesis, cell migration, proliferation, and survival by facilitating interactions between upstream receptors and downstream effectors. SHB is highly expressed in endothelial cells, hematopoietic cells, and pancreatic β-cells, where it regulates vascular development, immune responses, and glucose homeostasis. It is essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and integrin-dependent cytoskeletal reorganization, supporting endothelial cell migration and tubule formation. Dysregulation of SHB has been associated with cancer progression, diabetes, and autoimmune diseases due to its impact on angiogenic signaling, β-cell survival, and immune cell activation. Knockout studies reveal impaired angiogenesis, reduced β-cell mass, and defects in immune system development, underscoring its importance in vascular biology, immune regulation, and metabolic homeostasis.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Src Homology 2 Domain Containing Adapter Protein B (SHB)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser248-Leu484 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SHB
dry ice
No
availability
Shipped within 5-7 working days.
alias
SHB, bA3J10.2, SH2 domain containing adaptor protein B
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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