Human Src Homology 2 Domain Containing Adapter Protein B (SHB) Protein

Product specifications

Proteins and Peptides

Src Homology 2 Domain Containing Adapter Protein B (SHB)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 32.9 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ala252-Arg507
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q15464

SHB, bA3J10.2, SH2 domain containing adaptor protein B

Protein SHB

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SHB is an SH2 domain-containing adaptor protein that mediates signaling downstream of receptor tyrosine kinases, integrins, and cytokine receptors, linking activated receptors to intracellular signaling pathways like PI3K/Akt, MAPK, and VEGF signaling. It plays a critical role in processes such as angiogenesis, cell migration, proliferation, and survival by facilitating interactions between upstream receptors and downstream effectors. SHB is highly expressed in endothelial cells, hematopoietic cells, and pancreatic β-cells, where it regulates vascular development, immune responses, and glucose homeostasis. It is essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and integrin-dependent cytoskeletal reorganization, supporting endothelial cell migration and tubule formation. Dysregulation of SHB has been associated with cancer progression, diabetes, and autoimmune diseases due to its impact on angiogenic signaling, β-cell survival, and immune cell activation. Knockout studies reveal impaired angiogenesis, reduced β-cell mass, and defects in immune system development, underscoring its importance in vascular biology, immune regulation, and metabolic homeostasis.

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