Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody

Background

SHB is an SH2 domain-containing adaptor protein that mediates signaling downstream of receptor tyrosine kinases, integrins, and cytokine receptors, linking activated receptors to intracellular signaling pathways like PI3K/Akt, MAPK, and VEGF signaling. It plays a critical role in processes such as angiogenesis, cell migration, proliferation, and survival by facilitating interactions between upstream receptors and downstream effectors. SHB is highly expressed in endothelial cells, hematopoietic cells, and pancreatic β-cells, where it regulates vascular development, immune responses, and glucose homeostasis. It is essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and integrin-dependent cytoskeletal reorganization, supporting endothelial cell migration and tubule formation. Dysregulation of SHB has been associated with cancer progression, diabetes, and autoimmune diseases due to its impact on angiogenic signaling, β-cell survival, and immune cell activation. Knockout studies reveal impaired angiogenesis, reduced β-cell mass, and defects in immune system development, underscoring its importance in vascular biology, immune regulation, and metabolic homeostasis.