Src Homology 2 Domain Containing Adapter Protein B (SHB) Antibody
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Description
SHB Antibody is a Rabbit Polyclonal against SHB.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Src Homology 2 Domain Containing Adapter Protein B (SHB) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15464 |
| Gene ID | 6461 |
| Alias | SHB, bA3J10.2, SH2 domain containing adaptor protein B |
| Background | Antibody anti-SHB |
| Status | RUO |
Descripción
SHB is an SH2 domain-containing adaptor protein that mediates signaling downstream of receptor tyrosine kinases, integrins, and cytokine receptors, linking activated receptors to intracellular signaling pathways like PI3K/Akt, MAPK, and VEGF signaling. It plays a critical role in processes such as angiogenesis, cell migration, proliferation, and survival by facilitating interactions between upstream receptors and downstream effectors. SHB is highly expressed in endothelial cells, hematopoietic cells, and pancreatic β-cells, where it regulates vascular development, immune responses, and glucose homeostasis. It is essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and integrin-dependent cytoskeletal reorganization, supporting endothelial cell migration and tubule formation. Dysregulation of SHB has been associated with cancer progression, diabetes, and autoimmune diseases due to its impact on angiogenic signaling, β-cell survival, and immune cell activation. Knockout studies reveal impaired angiogenesis, reduced β-cell mass, and defects in immune system development, underscoring its importance in vascular biology, immune regulation, and metabolic homeostasis.
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