Family main features
The SET nuclear proto-oncogene, often referred to simply as SET, is a multifunctional protein involved in various cellular processes, including chromatin remodeling, apoptosis, and gene expression regulation. The SET protein was initially identified as a factor inhibiting the histone acetyltransferase activity of p300/CBP, which links it to chromatin structure regulation and transcriptional control. Overexpression of SET has been observed in several cancers, indicating its role in tumorigenesis and cancer progression. SET is also known to interact with various other proteins, influencing a range of cellular pathways and processes.
SET is composed of multiple domains that contribute to its diverse functions. The protein contains a nucleosome assembly protein (NAP) domain, which is involved in chromatin assembly and disassembly. Additionally, it has an acidic region that interacts with histones and other chromatin-associated proteins, and a C-terminal region implicated in various protein-protein interactions. The structure of SET allows it to function as a histone chaperone, influencing chromatin dynamics and gene expression.
SET belongs to the NAP family of proteins and is classified as a chromatin-associated protein. While the primary form of SET is well-characterized, alternative splicing can lead to different isoforms, potentially with distinct cellular functions. These isoforms may vary in their interactions with other proteins and their roles in cellular processes.
SET plays a crucial role in several cellular processes:
Overexpression of SET is linked to several cancers, including acute myeloid leukemia (AML), where it is associated with poor prognosis. Its role in inhibiting PP2A suggests that targeting SET could reactivate PP2A, offering a potential therapeutic strategy for cancer treatment. Furthermore, SET dysregulation is implicated in neurodegenerative diseases such as Alzheimer's disease, highlighting its importance in both oncology and neurology.
The SET nuclear proto-oncogene is a multifunctional protein with significant roles in chromatin remodeling, gene expression regulation, and apoptosis inhibition. Its structure facilitates interactions with various proteins, influencing diverse cellular processes. SET's overexpression in cancers and involvement in neurodegenerative diseases make it a critical focus of biomedical research, offering potential avenues for therapeutic intervention.
SET nuclear proto-oncogene
2PP2A,IGAAD,MRD58,TAF-I,I2PP2A,IPP2A2,PHAPII,TAF-IBETA,HLA-DR-associated protein II,Inhibitor of granzyme A-activated Dnase,Phosphatase 2A inhibitor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con SET nuclear proto-oncogene
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SET | abx365120 | Staphylococcal aureus Enterotoxin Total (SET) ELISA Kit | General | Milk, milk powder and yogurt. | Sandwich | 1600 | 96 tests | RUO | |||
Abbexa | SET | abx555962 | Human Protein SET (SET) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.18 ng/ml | 687.5 | 96 tests | Q01105 | RUO |
Abbexa | SET | abx556068 | Mouse Protein SET (SET) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.08 ng/ml | 687.5 | 96 tests | Q9EQU5 | RUO |
Abbexa | SET | abx556216 | Rat Protein SET (SET) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.16 ng/ml | 687.5 | 96 tests | Q63945 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SET | FNab07764 | anti- SET antibody | human | polyclonal | Rabbit | SET nuclear oncogene | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q01105 | RUO | |
Abbexa | SET | abx337312 | Protein SET (SET) Antibody (HRP) | Human | Polyclonal | Rabbit | Protein SET (SET) | HRP | ELISA | 162.5 | 20 µg | Q01105 | RUO | |
Abbexa | SET | abx338613 | Protein SET (SET) Antibody | Human | Polyclonal | Rabbit | Protein SET (SET) | Unconjugated | ELISA, WB | 162.5 | 20 µg | Q01105 | RUO | |
Abbexa | SET | abx430042 | Protein SET (SET) Antibody | Human | Polyclonal | Goat | Protein SET (SET) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | SET | abx028158 | Protein SET (SET) Antibody | Human | Polyclonal | Rabbit | Protein SET (SET) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q01105 | RUO | |
Abbexa | SET | abx337314 | Protein SET (SET) Antibody (Biotin) | Human | Polyclonal | Rabbit | Protein SET (SET) | Biotin | ELISA | 162.5 | 20 µg | Q01105 | RUO | |
Abbexa | SET | abx337313 | Protein SET (SET) Antibody (FITC) | Human | Polyclonal | Rabbit | Protein SET (SET) | FITC | 162.5 | 20 µg | Q01105 | RUO | ||
Abbexa | SET | abx237764 | Protein SET (SET) Antibody | Human | Polyclonal | Rabbit | Protein SET (SET) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q01105 | RUO | |
Abbexa | SET | abx004747 | Protein SET (SET) Antibody | Human | Polyclonal | Rabbit | Protein SET (SET) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q01105 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SET | abx261106 | Protein SET (SET) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q01105 | RUO | ||
FineTest | SET | P5614 | Recombinant Human SET | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q01105 | RUO |
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