Protein SET (SET) Antibody

Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-SET
proveedor
Abbexareference
abx028158Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL) induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Background
SET nuclear proto-oncogene is a gene that encodes a protein involved in regulating gene expression and chromatin remodeling SET is implicated in various cellular processes, including cell growth, differentiation, and apoptosis SET has been identified as a proto-oncogene, as its overexpression or misregulation contributes to tumorigenesis and cancer progression The SET protein interacts with other transcriptional and chromatin-modifying factors to regulate the structure of chromatin and gene transcription, playing a role in maintaining cellular homeostasis SET dysregulation is associated with several cancers, including leukemia and solid tumors, where its abnormal activity contributes to uncontrolled cell proliferation, survival, and metastasis SET is also involved in modulating stress responses and DNA repair, making it a key player in maintaining genomic stability and cellular integrity Its function in both normal cellular development and disease progression highlights its potential as a therapeutic target in cancer
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Protein SET (SET)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SET
dry ice
No
availability
Shipped within 5-10 working days.
alias
2PP2A,IGAAD,MRD58,TAF-I,I2PP2A,IPP2A2,PHAPII,TAF-IBETA,HLA-DR-associated protein II,Inhibitor of granzyme A-activated Dnase,Phosphatase 2A inhibitor
uniprot id
Quizá le pueda interesar
anti- SET antibody

proveedor
FineTestreference
FNab07764Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT)...
Precio a consultar
Ver másRecombinant Human SET

proveedor
FineTestreference
P5614Tested Applications
Western Blot,ELISAstatus
RUOPrecio a consultar
Ver másProtein SET (SET) Antibody

proveedor
Abbexareference
abx004747Tested Applications
WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalSET Antibody is a Rabbit Polyclonal antibody against SET. The protein encoded by this gene inhibits acetylation of nucle...
312€ (60 µl)
Ver más