anti- SET antibody
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Description
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SET nuclear oncogene |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 33 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q01105 |
| Gene ID | 6418 |
| Alias | 2PP2A,IGAAD,MRD58,TAF-I,I2PP2A,IPP2A2,PHAPII,TAF-IBETA,HLA-DR-associated protein II,Inhibitor of granzyme A-activated Dnase,Phosphatase 2A inhibitor |
| Background | Antibody anti-SET |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
SET nuclear proto-oncogene is a gene that encodes a protein involved in regulating gene expression and chromatin remodeling SET is implicated in various cellular processes, including cell growth, differentiation, and apoptosis SET has been identified as a proto-oncogene, as its overexpression or misregulation contributes to tumorigenesis and cancer progression The SET protein interacts with other transcriptional and chromatin-modifying factors to regulate the structure of chromatin and gene transcription, playing a role in maintaining cellular homeostasis SET dysregulation is associated with several cancers, including leukemia and solid tumors, where its abnormal activity contributes to uncontrolled cell proliferation, survival, and metastasis SET is also involved in modulating stress responses and DNA repair, making it a key player in maintaining genomic stability and cellular integrity Its function in both normal cellular development and disease progression highlights its potential as a therapeutic target in cancer
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