Family main features
SERPINF2, also known as alpha-2 antiplasmin (A2AP), is a crucial member of the serpin (serine protease inhibitor) family. It plays a vital role in regulating the fibrinolytic system by inhibiting plasmin, the enzyme responsible for breaking down fibrin clots. As part of the serpin superfamily, SERPINF2 helps to maintain hemostasis by preventing excessive clot breakdown, ensuring that clots remain stable during wound healing and tissue repair.
First characterized in the 1970s, SERPINF2 has since been extensively studied for its role in clot stabilization and its involvement in various bleeding disorders and thrombotic conditions. It is primarily synthesized in the liver and circulates in the plasma, where it acts as a major inhibitor of fibrinolysis.
The SERPINF2 protein is composed of 464 amino acids, with a molecular weight of approximately 70 kDa. Like other serpins, its structure features a central β-sheet and multiple α-helices. The reactive center loop (RCL), a hallmark of serpins, plays a crucial role in its inhibitory mechanism. The RCL of SERPINF2 interacts with plasmin to form a covalent complex, thereby inactivating the enzyme and preventing the degradation of fibrin clots.
Upon binding to plasmin, SERPINF2 undergoes a conformational change that traps plasmin in a covalent complex, rendering it inactive. This interaction is critical for ensuring that fibrinolysis is tightly regulated and that clots are broken down only when necessary.
SERPINF2 also contains a lysine-binding site, which facilitates its interaction with fibrin, allowing it to localize to sites of clot formation and provide targeted inhibition of plasmin activity. This ensures that clot breakdown occurs in a controlled manner, preventing premature clot dissolution and excessive bleeding.
SERPINF2 belongs to the clade F of the serpin superfamily, which is characterized by its role in inhibiting enzymes involved in fibrinolysis. While it shares structural similarities with other serpins, such as alpha-1 antitrypsin and SERPINF1, its function is distinct due to its specificity for plasmin.
There are no known subtypes of SERPINF2, but genetic variants and mutations can affect its function and lead to clinical conditions. These variants may alter the stability or inhibitory activity of SERPINF2, resulting in either an increased risk of bleeding (due to insufficient plasmin inhibition) or a predisposition to thrombosis (due to excessive clot stabilization).
The primary function of SERPINF2 is to regulate the fibrinolytic system by inhibiting plasmin, the enzyme responsible for breaking down fibrin clots. By doing so, it plays a crucial role in maintaining the balance between clot formation and clot breakdown, ensuring that clots remain stable during the initial stages of wound healing and are only dissolved once tissue repair is complete.
Mutations or deficiencies in the SERPINF2 gene can lead to several clinical conditions, primarily related to abnormal clotting or bleeding. The most notable conditions associated with SERPINF2 dysfunction include:
Given its role in regulating fibrinolysis, SERPINF2 has potential therapeutic applications in conditions where abnormal clotting or bleeding occurs. For example, recombinant SERPINF2 may be used to treat individuals with alpha-2 antiplasmin deficiency, helping to restore normal clot stabilization and prevent excessive bleeding.
In addition, inhibitors of SERPINF2 activity could be explored as potential therapies for thrombotic conditions, where excessive clot stabilization contributes to the development of abnormal blood clots. By reducing SERPINF2 activity, it may be possible to promote controlled clot breakdown and reduce the risk of thrombosis.
SERPINF2, or alpha-2 antiplasmin, is a critical regulator of the fibrinolytic system, ensuring that blood clots remain stable during wound healing and are only broken down when tissue repair is complete. By inhibiting plasmin, SERPINF2 prevents premature clot dissolution and plays a key role in maintaining hemostasis.
Mutations or deficiencies in SERPINF2 can lead to bleeding disorders, such as alpha-2 antiplasmin deficiency, where excessive plasmin activity results in uncontrolled clot breakdown and increased bleeding. On the other hand, dysregulation of SERPINF2 activity can contribute to thrombotic conditions by reducing the breakdown of abnormal blood clots.
Given its essential role in clot regulation, SERPINF2 has potential therapeutic applications in both bleeding and thrombotic disorders, making it a key target for further research and clinical development.
serpin family F member 2 (SERPINF2)
AAP,API,PLI,A2AP,alpha2AP,Alpha-2-antiplasmin,Alpha-2-AP,Alpha-2-plasmin inhibitor,Serpin F2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con SERPINF2 - serpin family F member 2
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Esta página contiene 27 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | SERPINF2 | abx575395 | Cow Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | P28800 | RUO | ||
Abbexa | SERPINF2 | abx150491 | Human Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx491162 | Human Alpha-2 Antiplasmin (SERPINF2) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.71 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx253372 | Human Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 12.5 ng/ml - 800 ng/ml | 7.5 ng/ml | 525 | 96 tests | P08697 | RUO |
Abbexa | SERPINF2 | abx197904 | Human Alpha-2 Antiplasmin (SERPINF2) CLIA Kit | Human | Serum, plasma and other biological fluids. | 0.31 ng/ml - 20 ng/ml | 0.19 ng/ml | 618.75 | 96 tests | RUO | ||
Abbexa | SERPINF2 | abx254509 | Mouse Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 3.125 ng/ml - 200 ng/ml | 1.88 ng/ml | 562.5 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx196709 | Mouse Alpha-2 Antiplasmin (SERPINF2) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 618.75 | 96 tests | RUO | ||
Abbexa | SERPINF2 | abx585311 | Mouse Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.127 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx362359 | Rabbit Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Rabbit | Serum, plasma and other biological fluids. | Sandwich | 0.47 ng/ml - 30 ng/ml | 0.29 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx353984 | Rat Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Rat | Plasma. | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.28 ng/ml | 675 | 96 tests | RUO | |
Abbexa | SERPINF2 | abx576086 | Rat Alpha-2 Antiplasmin (SERPINF2) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 3.125 ng/ml - 200 ng/ml | 1.88 ng/ml | 525 | 96 tests | Q80ZA3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | SERPINF2 | abx022448 | alpha 2 Antiplasmin (SERPINF2) Antibody | Monoclonal | Mouse | alpha 2 Antiplasmin (SERPINF2) | Unconjugated | ELISA, WB | 2137.5 | 1 mg | RUO | |||
Abbexa | SERPINF2 | abx432316 | alpha 2-Antiplasmin (SERPINF2) Antibody | Human | Polyclonal | Goat | alpha 2-Antiplasmin (SERPINF2) | Unconjugated | P-ELISA, WB, IHC, IF/ICC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | SERPINF2 | abx102505 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Human | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | P08697 | RUO | |
Abbexa | SERPINF2 | abx211298 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Human | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P08697 | RUO | |
Abbexa | SERPINF2 | abx230339 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Human | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | ELISA, WB | 350 | 100 µg | P08697 | RUO | |
Abbexa | SERPINF2 | abx115475 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Human | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P08697 | RUO | |
Abbexa | SERPINF2 | abx102506 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Mouse | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | SERPINF2 | abx135865 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Mouse | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | WB, IHC | 175 | 20 µl | P08697 | RUO | |
Abbexa | SERPINF2 | abx102507 | Alpha-2 Antiplasmin (SERPINF2) Antibody | Rat | Polyclonal | Rabbit | Alpha-2 Antiplasmin (SERPINF2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | SERPINF2 | P0511 | Recombinant Human SERPINF2 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P08697 | RUO | ||
Abbexa | SERPINF2 | abx694273 | Mouse Alpha-2-Antiplasmin (SERPINF2) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q61247 | RUO | |
Abbexa | SERPINF2 | abx065261 | Mouse Alpha-2 Antiplasmin (SERPINF2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q61247 | RUO |
Abbexa | SERPINF2 | abx691905 | Mouse alpha 2-Antiplasmin (SerpinF2) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 975 | 50 µg | Q61247 | RUO | |
Abbexa | SERPINF2 | abx065260 | Human Alpha-2 Antiplasmin (SERPINF2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P08697 | RUO |
Abbexa | SERPINF2 | abx680468 | Mouse Alpha-2 Antiplasmin (SERPINF2) Protein | Mouse | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | SERPINF2 | abx065262 | Rat Alpha-2 Antiplasmin (SERPINF2) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q68FT8 | RUO |
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