Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI).
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL. )Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin. Plasmin participates in fibrinolysis degrading Fibrin and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.[6]
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). Alfa 2-antiplasmina (o α2-antiplasmina o plasmina inhibidor) es un inhibidor de la serina proteasa responsable de inactivar la plasmina. La plasmina participa en la fibrinólisis, degradando la fibrina y la degradación de varias otras proteínas. Esta proteína está codificada por el gen SERPINF2 .[6]
Primary Antibodies
Polyclonal
Rat
Alpha-2 Antiplasmin (SERPINF2)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
100 µl
200 µl
1 ml
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SERPINF2
No
Shipped within 5-7 working days.
AAP,API,PLI,A2AP,alpha2AP,Alpha-2-antiplasmin,Alpha-2-AP,Alpha-2-plasmin inhibitor,Serpin F2
This product is for research use only.
Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI).
250€ (100 µl)
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