Family main features
SERPINE2, also known as protease nexin-1 (PN-1), is a member of the serpin (serine protease inhibitor) superfamily, which is involved in regulating a wide variety of proteases across different physiological processes. Unlike its closely related counterpart, SERPINE1 (PAI-1), which predominantly regulates fibrinolysis, SERPINE2 plays a more diverse role in modulating tissue remodeling, inflammation, and cellular homeostasis by inhibiting a variety of proteases. These include thrombin, trypsin, urokinase-type plasminogen activator (uPA), and other serine proteases that participate in hemostasis, extracellular matrix degradation, and inflammation.
SERPINE2 is expressed in a wide range of tissues, including the brain, lungs, kidneys, and cardiovascular system. Its ability to inhibit multiple serine proteases grants it a broad functional role in physiological processes ranging from coagulation to inflammation. Dysregulation of SERPINE2 has been implicated in a number of pathological conditions, such as chronic obstructive pulmonary disease (COPD), cardiovascular diseases, and certain forms of cancer.
SERPINE2 is a glycoprotein of approximately 43 kDa in its mature form, consisting of 414 amino acids. Like other members of the serpin family, SERPINE2 exhibits a characteristic tertiary structure, comprising a central β-sheet core and several α-helices. The reactive center loop (RCL), a flexible segment of the protein, is responsible for the interaction with and inhibition of target proteases. The RCL acts as a "bait" for proteases; once the protease attempts to cleave the loop, SERPINE2 undergoes a dramatic conformational shift that traps the protease in an inactive complex.
The structure of SERPINE2 allows it to form a stable covalent complex with its target proteases, effectively neutralizing their activity. This mechanism is similar to that seen in other serpins like PAI-1. However, SERPINE2 has a broader range of protease targets, including thrombin and plasminogen activators, making it an important regulator of both fibrinolysis and coagulation.
Another important feature of SERPINE2 is its glycosylation, which influences its stability, circulation time, and interactions with extracellular matrix components. The presence of N-linked glycosylation sites on the protein ensures proper folding and prolongs its half-life in the bloodstream, which is crucial for its function in tissue remodeling and inflammation.
SERPINE2 is classified under the "E" group of serpins due to its inhibitory role in various extracellular proteases. While SERPINE2 itself is a single gene product, genetic variants have been identified that influence its expression and function. These polymorphisms can lead to differential protease inhibition and altered susceptibility to certain diseases, such as cardiovascular conditions or pulmonary disorders.
One notable feature of SERPINE2 is its overlap with other serine protease inhibitors in terms of function. For example, both SERPINE1 and SERPINE2 can inhibit urokinase-type plasminogen activator (uPA), although SERPINE1 is more specifically involved in inhibiting plasminogen activators in the context of fibrinolysis. In contrast, SERPINE2 has a broader range of protease targets and is active in more tissues, particularly the brain and lungs.
SERPINE2's biological functions span several key physiological processes due to its ability to inhibit a variety of serine proteases. The most well-characterized functions of SERPINE2 include its roles in:
SERPINE2's role in regulating proteases has made it a subject of interest in various diseases where protease dysregulation is a contributing factor. Some of the key clinical issues related to SERPINE2 include:
SERPINE2 (protease nexin-1) is a versatile serine protease inhibitor that regulates a broad range of physiological processes, including coagulation, fibrinolysis, tissue remodeling, and inflammation. Its ability to inhibit multiple proteases, including thrombin, uPA, and elastase, makes it an important player in maintaining tissue homeostasis and protecting against protease-mediated damage. Dysregulation of SERPINE2 activity is associated with a variety of pathological conditions, including pulmonary diseases, cardiovascular disorders, neurodegeneration, and cancer. As such, SERPINE2 is a critical regulator of protease activity in multiple tissues and a potential therapeutic target for diseases where protease imbalance contributes to pathology. Understanding its mechanisms of action and regulatory pathways will be crucial for developing strategies to modulate SERPINE2 activity in clinical settings.
serpin family E member 2 (SERPINE2)
GDN,PI7,PN1,PNI,PI-7,PN-1,GDNPF,Glia-derived nexin,Peptidase inhibitor 7,Protease nexin 1,Protease nexin I,Serpin E2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con SERPINE2 - serpin family E member 2
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Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | SERPINE2 | abx496339 | Human Glia Derived Nexin / GDN (SERPINE2) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.135 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | SERPINE2 | abx151668 | Human Glia Derived Nexin / GDN (SERPINE2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.061 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | SERPINE2 | abx252530 | Human Glia Derived Nexin / GDN (SERPINE2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 562.5 | 96 tests | P07093 | RUO |
Abbexa | SERPINE2 | abx494242 | Human Glia Derived Nexin / GDN (SERPINE2) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.062 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | SERPINE2 | abx258751 | Human Glia Derived Nexin / GDN (SERPINE2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | SERPINE2 | abx254122 | Mouse Glia Derived Nexin / GDN (SERPINE2) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 6.25 pg/ml - 400 pg/ml | 3.75 pg/ml | 562.5 | 96 tests | Q07235 | RUO |
Abbexa | SERPINE2 | abx256958 | Rat Glia Derived Nexin / GDN (SERPINE2) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 6.25 pg/ml - 400 pg/ml | 3.75 pg/ml | 562.5 | 96 tests | P07092 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | SERPINE2 | FNab07752 | anti- SERPINE2 antibody | human | monoclonal | Mouse | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2 | IgG1 | Unconjugated | ELISA, WB | 100µg | P07093 | RUO | |
FineTest | SERPINE2 | FNab07751 | anti- SERPINE2 antibody | human | polyclonal | Rabbit | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2 | IgG | Unconjugated | ELISA, IHC, WB, IP | 100µg | P07093 | RUO | |
Abbexa | SERPINE2 | abx122030 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | SERPINE2 | abx128989 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P07093 | RUO | |
Abbexa | SERPINE2 | abx026914 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P07093 | RUO | |
Abbexa | SERPINE2 | abx237752 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Monoclonal | Mouse | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB | 350 | 100 µg | P07093 | RUO | |
Abbexa | SERPINE2 | abx172541 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Monoclonal | Mouse | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | SERPINE2 | abx241290 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, IHC | 250 | 50 µl | P07093 | RUO | |
Abbexa | SERPINE2 | abx237751 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | P07093 | RUO | |
Abbexa | SERPINE2 | abx115474 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | P07093 | RUO | |
Abbexa | SERPINE2 | abx241918 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Human | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P07093 | RUO | |
Abbexa | SERPINE2 | abx004074 | Glia Derived Nexin / GDN (SERPINE2) Antibody | Mouse | Polyclonal | Rabbit | Glia Derived Nexin / GDN (SERPINE2) | Unconjugated | WB | 175 | 20 µl | P07093 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | SERPINE2 | abx168202 | Human Glia Derived Nexin / GDN (SERPINE2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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