SERPINE2 antibody
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Name
SERPINE2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab07751
Tested Applications
ELISA, IHC, WB, IP
Description
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 44-50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P07093 |
| Gene ID | 5270 |
| Alias | GDN,PI7,PN1,PNI,PI-7,PN-1,GDNPF,Glia-derived nexin,Peptidase inhibitor 7,Protease nexin 1,Protease nexin I,Serpin E2 |
| Background | Antibody anti-SERPINE2 |
| Status | RUO |
| Note | Mol. Weight 44-50 kDa |
Background
SERPINE2, also known as protease nexin-1 (PN-1), is a member of the serpin (serine protease inhibitor) superfamily, which is involved in regulating a wide variety of proteases across different physiological processes. Unlike its closely related counterpart, SERPINE1 (PAI-1), which predominantly regulates fibrinolysis, SERPINE2 plays a more diverse role in modulating tissue remodeling, inflammation, and cellular homeostasis by inhibiting a variety of proteases. These include thrombin, trypsin, urokinase-type plasminogen activator (uPA), and other serine proteases that participate in hemostasis, extracellular matrix degradation, and inflammation. SERPINE2 is expressed in a wide range of tissues, including the brain, lungs, kidneys, and cardiovascular system. Its ability to inhibit multiple serine proteases grants it a broad functional role in physiological processes ranging from coagulation to inflammation.
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