This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Glia Derived Nexin (GDN) Antibody is a Mouse Monoclonal antibody against Glia Derived Nexin (GDN).
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL. )SERPINE2 is a protein capable of inhibiting various proteases, including thrombin, urokinase, plasmin, and trypsin, and it is encoded by the SERPINE2 gene in humans, which is also known by aliases such as GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, and serpin family E member 2.
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINE2 es una proteína capaz de inhibir varias proteasas, incluidas trombina, uroquinasa, plasmina y tripsina, y está codificado por el gen SERPINE2 en humanos, que también se conoce con alias como GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI y miembro 2 familia E de las serpinas.
Primary Antibodies
Monoclonal
Human
Glia Derived Nexin / GDN (SERPINE2)
Mouse
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by Protein A and Protein G affinity chromatography.
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
1 ml
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SERPINE2
No
Please enquire.
GDN,PI7,PN1,PNI,PI-7,PN-1,GDNPF,Glia-derived nexin,Peptidase inhibitor 7,Protease nexin 1,Protease nexin I,Serpin E2
This product is for research use only.
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