Glia Derived Nexin / GDN (SERPINE2) Antibody
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Description
SERPINE2 Antibody is a Rabbit Polyclonal against SERPINE2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glia Derived Nexin / GDN (SERPINE2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07093 |
| Gene ID | 5270 |
| Alias | GDN,PI7,PN1,PNI,PI-7,PN-1,GDNPF,Glia-derived nexin,Peptidase inhibitor 7,Protease nexin 1,Protease nexin I,Serpin E2 |
| Background | Antibody anti-SERPINE2 |
| Status | RUO |
Descripción
SERPINE2, also known as protease nexin-1 (PN-1), is a member of the serpin (serine protease inhibitor) superfamily, which is involved in regulating a wide variety of proteases across different physiological processes. Unlike its closely related counterpart, SERPINE1 (PAI-1), which predominantly regulates fibrinolysis, SERPINE2 plays a more diverse role in modulating tissue remodeling, inflammation, and cellular homeostasis by inhibiting a variety of proteases. These include thrombin, trypsin, urokinase-type plasminogen activator (uPA), and other serine proteases that participate in hemostasis, extracellular matrix degradation, and inflammation. SERPINE2 is expressed in a wide range of tissues, including the brain, lungs, kidneys, and cardiovascular system. Its ability to inhibit multiple serine proteases grants it a broad functional role in physiological processes ranging from coagulation to inflammation.
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