Family main features
PTGIR, also known as the prostacyclin receptor, is a G-protein-coupled receptor (GPCR) that mediates the effects of prostacyclin (prostaglandin I2, PGI2), a lipid-derived signaling molecule. Prostacyclin is primarily produced by endothelial cells and plays a critical role in regulating vascular homeostasis, inflammation, and platelet aggregation. By binding to PTGIR, prostacyclin activates intracellular signaling pathways that lead to vasodilation, inhibition of platelet aggregation, and modulation of immune responses. PTGIR is highly expressed in vascular smooth muscle cells, endothelial cells, and platelets, as well as in other tissues, including the lungs and kidneys. Dysregulation of PTGIR signaling is implicated in cardiovascular diseases, pulmonary hypertension, and inflammation-related disorders.
PTGIR is a typical GPCR consisting of approximately 386 amino acids and characterized by the following structural features:
The structural configuration of PTGIR ensures precise signaling responses to prostacyclin binding.
PTGIR is part of the prostaglandin receptor family, which belongs to the class A (rhodopsin-like) GPCRs. This family includes receptors for other prostaglandins, such as EP (PGE2 receptors) and TP (thromboxane receptor). PTGIR specifically binds prostacyclin with high selectivity and does not respond to other prostaglandins under physiological conditions.
PTGIR mediates the diverse physiological effects of prostacyclin, including:
These functions underscore PTGIR’s critical role in maintaining vascular integrity, preventing thrombosis, and modulating inflammatory responses.
Dysregulation of PTGIR signaling is implicated in a variety of diseases:
PTGIR is a GPCR that mediates the effects of prostacyclin, regulating vascular tone, platelet aggregation, and inflammation. Its structure includes seven transmembrane domains, extracellular ligand-binding sites, and intracellular regions for G-protein coupling and signal transduction. PTGIR’s critical roles in cardiovascular protection and pulmonary function underscore its therapeutic importance. Dysregulation of PTGIR signaling contributes to conditions such as hypertension, thrombosis, PAH, and chronic inflammatory diseases, highlighting its significance as a potential drug target in cardiovascular and inflammatory disorders.
Prostacyclin Receptor (PTGIR)
PTGIR,prostanoid IP receptor,prostacyclin receptor,prostaglandin I2 receptor,prostaglandin I2 (prostacyclin) receptor,IP, ,PRIPR
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, ELISA Kits, Primary Antibodies) relacionados con PTGIR - Prostacyclin Receptor
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Esta página contiene 7 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PTGIR | abx493985 | Human Prostacyclin Receptor (PTGIR) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | PTGIR | abx152844 | Human Prostacyclin Receptor (PTGIR) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | P43119 | RUO |
Abbexa | PTGIR | abx538779 | Mouse Prostacyclin Receptor (PTGIR) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | P43252 | RUO |
Abbexa | PTGIR | abx538780 | Rat Prostacyclin Receptor (PTGIR) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | P43253 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PTGIR | abx324149 | Prostacyclin Receptor (PTGIR) Antibody | Human | Polyclonal | Rabbit | Prostacyclin Receptor (PTGIR) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | P43119 | RUO | |
Abbexa | PTGIR | abx001529 | Prostacyclin Receptor (PTGIR) Antibody | Human | Polyclonal | Rabbit | Prostacyclin Receptor (PTGIR) | Unconjugated | WB, IHC | 175 | 20 µl | P43119 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PTGIR | abx654819 | Human Prostacyclin Receptor (PTGIR) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2162.5 | 1 mg | RUO |
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