Mouse Prostacyclin Receptor (PTGIR) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PTGIR
proveedor
Abbexareference
abx538779Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Prostacyclin Receptor (PTGIR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Prostacyclin Receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
The prostacyclin receptor (PTGIR), also known as IP, is a G protein-coupled receptor activated by prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. PTGIR couples to Gs proteins, stimulating adenylate cyclase, increasing cAMP levels, and promoting downstream signaling that leads to smooth muscle relaxation and inhibition of platelet activation. PTGIR is expressed in endothelial cells, vascular smooth muscle, and platelets, where it plays a critical role in maintaining vascular homeostasis, reducing thrombosis, and regulating inflammation. Prostacyclin analogs, such as epoprostenol and iloprost, are used clinically to treat pulmonary arterial hypertension (PAH) by improving vasodilation and reducing vascular resistance. Dysregulation of PTGIR signaling is implicated in cardiovascular diseases, thrombosis, and inflammatory conditions. PTGIR remains a valuable therapeutic target for vascular disorders due to its ability to promote vasodilation, inhibit platelet aggregation, and protect against endothelial dysfunction.
Características del producto
category
ELISA Kits
immunogen target
Prostacyclin Receptor (PTGIR)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PTGIR,prostanoid IP receptor,prostacyclin receptor,prostaglandin I2 receptor,prostaglandin I2 (prostacyclin) receptor,IP ,PRIPR
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PTGIR
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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