Human Prostacyclin Receptor (PTGIR) Protein
221€ (10 µg)
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Name
Human Prostacyclin Receptor (PTGIR) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx654819
Tested Applications
WB, SDS-PAGE
Description
Human Prostacyclin Receptor (PTGIR) Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Prostacyclin Receptor (PTGIR) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Arg296-Cys386 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | PTGIR,prostanoid IP receptor,prostacyclin receptor,prostaglandin I2 receptor,prostaglandin I2 (prostacyclin) receptor,IP ,PRIPR |
| Background | Protein PTGIR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
The prostacyclin receptor (PTGIR), also known as IP, is a G protein-coupled receptor activated by prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. PTGIR couples to Gs proteins, stimulating adenylate cyclase, increasing cAMP levels, and promoting downstream signaling that leads to smooth muscle relaxation and inhibition of platelet activation. PTGIR is expressed in endothelial cells, vascular smooth muscle, and platelets, where it plays a critical role in maintaining vascular homeostasis, reducing thrombosis, and regulating inflammation. Prostacyclin analogs, such as epoprostenol and iloprost, are used clinically to treat pulmonary arterial hypertension (PAH) by improving vasodilation and reducing vascular resistance. Dysregulation of PTGIR signaling is implicated in cardiovascular diseases, thrombosis, and inflammatory conditions. PTGIR remains a valuable therapeutic target for vascular disorders due to its ability to promote vasodilation, inhibit platelet aggregation, and protect against endothelial dysfunction.
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