Family main features
Pentraxin 3 (PTX3) is a member of the pentraxin family of proteins, which are characterized by their cyclic multimeric structure and their ability to recognize and bind to various targets, including pathogens, damaged cells, and extracellular matrix components. PTX3 is an essential component of the innate immune system and plays important roles in inflammation, host defense, tissue repair, and regulation of the immune response. PTX3 is a long pentraxin, meaning it has an extended structure compared to short pentraxins like C-reactive protein (CRP). It is composed of five identical subunits arranged in a pentameric ring structure. Each subunit contains a conserved C-terminal domain known as the pentraxin domain, which is responsible for ligand binding, and a unique N-terminal domain involved in oligomerization and interaction with other proteins. PTX3 is produced and secreted by various cell types, including immune cells (such as macrophages, dendritic cells, and neutrophils), endothelial cells, fibroblasts, and certain epithelial cells, in response to inflammatory stimuli, microbial infection, and tissue injury. Its expression can be induced rapidly following activation of innate immune receptors or exposure to pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α).PTX3 plays a critical role in innate immunity by recognizing and binding to a wide range of microbial pathogens, including bacteria, fungi, and viruses. It acts as a soluble pattern recognition receptor (PRR) that opsonizes pathogens, promotes their clearance by phagocytic cells, and activates the complement system to enhance immune responses against invading microorganisms. PTX3 is also involved in the regulation of inflammation by modulating the activity of immune cells, such as macrophages, neutrophils, and dendritic cells. It can amplify inflammatory responses by promoting cytokine production and leukocyte recruitment to sites of infection or tissue damage, but it also has anti-inflammatory effects by limiting excessive inflammation and tissue damage.PTX3 contributes to tissue repair and remodeling following injury or infection by promoting angiogenesis, extracellular matrix remodeling, and wound healing. It stimulates the proliferation and migration of endothelial cells, enhances tissue regeneration, and supports the resolution of inflammation.
Pentraxin 3 (PTX3) is a multifunctional protein that plays a crucial role in innate immunity, inflammation, and tissue remodeling. Structurally distinct from the short pentraxins CRP and SAP, PTX3 is produced by various cell types in response to inflammatory stimuli and microbial recognition. It facilitates pathogen recognition and clearance, activates the complement system, and modulates immune cell activity. Clinically, PTX3 is a valuable biomarker for inflammatory diseases, infections, and cardiovascular conditions. Its involvement in cancer progression and reproductive health further underscores its broad biological significance and potential as a therapeutic target.
Pentraxin 3 (PTX3)
TSG-14,TNFAIP5,Pentaxin-related protein PTX3,Tumor necrosis factor alpha-induced protein 5,TNF alpha-induced protein 5
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con PTX3 - Pentraxin 3
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Esta página contiene 37 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | PTX3 | abx512452 | Cow Pentraxin 3 (PTX3) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | Q0VCG9 | RUO | ||
FineTest | PTX3 | EH0263 | Human PTX3(Pentraxin 3) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | P26022 | RUO | ||
Abbexa | PTX3 | abx252008 | Human Pentraxin 3 (PTX3) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78.13 pg/ml - 5000 pg/ml | 46.88 pg/ml | 525 | 96 tests | P26022 | RUO |
Abbexa | PTX3 | abx152696 | Human Pentraxin 3 (PTX3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids,saliva | Sandwich | 93.8 pg/ml - 6000 pg/ml | < 33.9 pg/ml | 687.5 | 96 tests | P26022 | RUO |
Abbexa | PTX3 | abx495857 | Human Pentraxin 3 (PTX3) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, salivas and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.113 ng/ml | 812.5 | 96 tests | P26022 | RUO |
Abbexa | PTX3 | abx197413 | Human Pentraxin 3 (PTX3) CLIA Kit | Human | Serum, plasma and other biological fluids. | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 618.75 | 96 tests | P26022 | RUO | |
Abbexa | PTX3 | abx585230 | Human Anti-Pentraxin 3 Antibody (Anti-PTX3) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Indirect | 31.2 pg/ml - 2000 pg/ml | < 13.3 pg/ml | 800 | 96 tests | RUO | |
Abbexa | PTX3 | abx496612 | Human Pentraxin 3 Antibody (PTX3 Ab) CLIA Kit | Human | Serum, plasma and other biological fluids. | Indirect | 31.2 pg/ml - 2000 pg/ml | < 13.3 pg/ml | 962.5 | 96 tests | RUO | |
FineTest | PTX3 | EM0161 | Mouse PTX3/Pentraxin 3(Pentraxin-related protein PTX3) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P48759 | RUO | ||
Abbexa | PTX3 | abx495858 | Mouse Pentraxin 3 (PTX3) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 13.5 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | PTX3 | abx156970 | Mouse Pentraxin 3 (PTX3) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 13.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | PTX3 | abx361033 | Pig Pentraxin 3 (PTX3) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 618.75 | 96 tests | F1SJM0 | RUO |
FineTest | PTX3 | ER1301 | Rat PTX3(Pentraxin 3) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | D3ZT94 | RUO | ||
Abbexa | PTX3 | abx495859 | Rat Pentraxin 3 (PTX3) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 13.6 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | PTX3 | abx255967 | Rat Pentraxin 3 (PTX3) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 531.25 | 96 tests | D3ZT94 | RUO |
Abbexa | PTX3 | abx155960 | Rat Pentraxin 3 (PTX3) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.6 pg/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | PTX3 | FNab06306 | anti- Pentraxin 3 antibody | human | polyclonal | Rabbit | Pentraxin-related protein PTX3 | IgG | Unconjugated | ELISA, WB | 100µg | P26022 | RUO | |
Abbexa | PTX3 | abx028325 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB | 281.25 | 80 µl | P26022 | RUO | |
Abbexa | PTX3 | abx336952 | Pentraxin 3 (PTX3) Antibody (HRP) | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | HRP | ELISA | 162.5 | 20 µg | P26022 | RUO | |
Abbexa | PTX3 | abx101653 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P26022 | RUO | |
Abbexa | PTX3 | abx402584 | Pentraxin-related protein PTX3 (PTX3) Antibody | Human | Monoclonal | Rabbit | Pentraxin-related protein PTX3 (PTX3) | Unconjugated | ELISA, FCM | 287.5 | 50 µl | P26022 | RUO | |
Abbexa | PTX3 | abx173973 | Pentraxin 3 (PTX3) Antibody | Human | Monoclonal | Mouse | Pentraxin 3 (PTX3) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | P26022 | RUO | |
Abbexa | PTX3 | abx336954 | Pentraxin 3 (PTX3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Biotin | ELISA | 162.5 | 20 µg | P26022 | RUO | |
Abbexa | PTX3 | abx336953 | Pentraxin 3 (PTX3) Antibody (FITC) | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | FITC | 162.5 | 20 µg | P26022 | RUO | ||
Abbexa | PTX3 | abx326094 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P26022 | RUO | |
Abbexa | PTX3 | abx013442 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB, IF/ICC | 43.75 | 10 µg | P26022 | RUO | |
Abbexa | PTX3 | abx211852 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P26022 | RUO | |
Abbexa | PTX3 | abx213113 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P26022 | RUO | |
Abbexa | PTX3 | abx114366 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P26022 | RUO | |
Abbexa | PTX3 | abx236306 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB | 350 | 100 µg | P26022 | RUO | |
Abbexa | PTX3 | abx338836 | Pentraxin 3 (PTX3) Antibody | Human | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P26022 | RUO | |
Abbexa | PTX3 | abx101654 | Pentraxin 3 (PTX3) Antibody | Mouse | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P48759 | RUO | |
Abbexa | PTX3 | abx173974 | Pentraxin 3 (PTX3) Antibody | Rat | Monoclonal | Mouse | Pentraxin 3 (PTX3) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | PTX3 | abx101655 | Pentraxin 3 (PTX3) Antibody | Rat | Polyclonal | Rabbit | Pentraxin 3 (PTX3) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | D3ZT94 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PTX3 | abx068442 | Mouse Pentraxin 3 (PTX3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P48759 | RUO |
Abbexa | PTX3 | abx068440 | Human Pentraxin 3 (PTX3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P26022 | RUO |
Abbexa | PTX3 | abx068441 | Rat Pentraxin 3 (PTX3) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | D3ZT94 | RUO |
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