Rat Pentraxin 3 (PTX3) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein PTX3
proveedor
Abbexareference
abx068441Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Pentraxin 3 is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
PTX3 is a long pentraxin and key component of the innate immune system involved in recognizing pathogens, regulating inflammation, and facilitating tissue repair PTX3 is produced by various cell types, including macrophages, neutrophils, and endothelial cells, in response to inflammatory stimuli such as IL-1β, TNF-α, and Toll-like receptor activation It acts as a soluble pattern recognition receptor (PRR), binding microbial components, such as fungal conidia, and activating complement pathways to enhance pathogen clearance PTX3 also regulates angiogenesis and extracellular matrix remodeling during tissue repair Elevated PTX3 levels are observed in conditions like sepsis, cardiovascular disease, and autoimmune disorders, where it acts as a biomarker for inflammation and disease progression PTX3 plays protective roles in infections, while dysregulated expression contributes to chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis, where it modulates both innate and adaptive immunity
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Pentraxin 3 (PTX3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.0 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser195-Ser381 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
PTX3
dry ice
No
availability
Shipped within 5-7 working days.
alias
TSG-14,TNFAIP5,Pentaxin-related protein PTX3,Tumor necrosis factor alpha-induced protein 5,TNF alpha-induced protein 5
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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