Family main features
Nexilin, encoded by the NEXN gene, is a crucial protein involved in the maintenance and regulation of the actin cytoskeleton. It was first identified through its interaction with F-actin, an essential component of the cytoskeleton, which is involved in various cellular processes including shape maintenance, motility, and intracellular transport. Nexilin is highly expressed in cardiac muscle cells and skeletal muscle cells, highlighting its importance in the function and integrity of muscle tissues. The protein is essential for normal cardiac function and structural integrity, making it a significant player in cardiac health and disease.
Nexilin is a large protein, consisting of several distinct structural domains:
Nexilin belongs to the family of F-actin binding proteins, which are characterized by their ability to interact with filamentous actin. This family includes a variety of proteins involved in cytoskeletal organization and cellular dynamics. While Nexilin itself does not have subtypes, it interacts with multiple other proteins within the cytoskeletal and signaling networks.
Nexilin plays several critical roles in cellular function and integrity:
Mutations and dysregulation of the NEXN gene have been implicated in several clinical conditions, particularly those related to cardiac function:
Nexilin (NEXN) is a crucial F-actin binding protein with essential roles in maintaining the structural integrity and function of muscle tissues, particularly in the heart. Its ability to stabilize actin filaments makes it integral to the mechanical stability and contractility of cardiomyocytes. Mutations in NEXN are linked to serious cardiac conditions, including dilated and hypertrophic cardiomyopathy, highlighting its importance in cardiovascular health. Research continues to uncover the detailed mechanisms of Nexilin's function and its broader implications in muscle biology and disease, making it a significant target for therapeutic interventions in muscle-related disorders.
nexilin F-actin binding protein (NEXN)
CMH20,NELIN,F-actin-binding protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con NEXN - nexilin F-actin binding protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 12 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | NEXN | EH4351 | Human NEXN(Nexilin) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q0ZGT2 | RUO | ||
Abbexa | NEXN | abx534939 | Human Putative uncharacterized protein NEXN-AS1 (NEXN-AS1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8NBZ9 | RUO | ||
Abbexa | NEXN | abx495472 | Human Nexilin (NEXN) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 6.1 pg/ml | 812.5 | 96 tests | Q0ZGT2 | RUO |
Abbexa | NEXN | abx152514 | Human Nexilin (NEXN) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.5 pg/ml | 687.5 | 96 tests | Q0ZGT2 | RUO |
Abbexa | NEXN | abx585532 | Mouse Nexilin (NEXN) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | NEXN | abx585533 | Rat Nexilin (NEXN) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEXN | abx177803 | Nexilin (NEXN) Antibody | Human | Polyclonal | Rabbit | Nexilin (NEXN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q0ZGT2 | RUO | |
Abbexa | NEXN | abx129329 | Nexilin (NEXN) Antibody | Mouse | Polyclonal | Rabbit | Nexilin (NEXN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | NEXN | abx100201 | Nexilin (NEXN) Antibody | Rat | Polyclonal | Rabbit | Nexilin (NEXN) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q9Z2J4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEXN | abx654557 | Human Nexilin (NEXN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q0ZGT2 | RUO |
Abbexa | NEXN | abx068288 | Rat Nexilin (NEXN) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9Z2J4 | RUO |
Abbexa | NEXN | abx167347 | Mouse Nexilin (NEXN) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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