Family main features
Interferon-alpha 5 (IFN-α5) is part of the type I interferon family, a group of cytokines that play a critical role in the innate immune response. Type I interferons, including IFN-α5, are primarily responsible for defending the body against viral infections and stimulating immune responses. The IFN-α family includes several subtypes, all of which are encoded by distinct genes, with similar but non-identical functions. IFN-α5, like other interferons, is produced by immune cells such as dendritic cells and macrophages in response to viral infection or other pathogenic threats.
The production of IFN-α5 is induced by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), that recognize pathogen-associated molecular patterns (PAMPs). Once produced, IFN-α5 exerts its effects by binding to the interferon-alpha/beta receptor (IFNAR), initiating a cascade of intracellular signaling events that culminate in the activation of numerous interferon-stimulated genes (ISGs). These ISGs orchestrate the antiviral state, hindering viral replication and spread.
While IFN-α2 is the most widely studied and clinically utilized subtype, IFN-α5 and other subtypes have unique properties and may exhibit different antiviral, antitumor, and immunomodulatory effects. IFN-α5 has shown significance in antiviral responses and potentially in autoimmune diseases and cancer through its interaction with immune cells and modulation of immune pathways.
The protein structure of IFN-α5 is characteristic of type I interferons, sharing significant homology with other IFN-α subtypes but with subtle differences that may impact its receptor binding and biological activity.
IFN-α5 is classified under the type I interferon family, which includes IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω. Within the IFN-α family, there are at least 13 different subtypes, each encoded by a separate gene but sharing similar sequences and functions.
While the IFN-α subtypes all act through the same receptor complex (IFNAR), they can have varying potency and specificity in terms of antiviral, antitumor, and immunoregulatory effects. These differences arise from minor variations in their amino acid sequences, which can influence their interaction with the receptor and downstream signaling.
Despite its strong antiviral and immunomodulatory properties, IFN-α5 is less commonly used in clinical settings compared to IFN-α2. However, it has potential therapeutic implications for viral infections, cancer, and autoimmune diseases.
Interferon-alpha 5 (IFN-α5) is a member of the type I interferon family, playing a critical role in antiviral defense, immune modulation, and tumor suppression. Structurally, IFN-α5 shares significant similarities with other type I interferons, consisting of α-helices that enable its interaction with the IFNAR receptor, leading to the activation of the JAK-STAT signaling pathway and transcription of interferon-stimulated genes. While it shares common functions with other IFN-α subtypes, IFN-α5 exhibits unique antiviral and immunomodulatory properties, making it an important, though less studied, component of the immune system. Its therapeutic potential in viral infections, cancer, and autoimmune diseases is promising, but its clinical use is limited due to side effects and the availability of better-studied interferon subtypes.
interferon alpha 5 (IFNA5)
INA5,INFA5,leIF G,IFN-alphaG,IFN-alpha-5,Interferon alpha-61,Interferon alpha-G
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con IFNA5 - interferon alpha 5
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 22 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | IFNA5 | abx528087 | Human Interferon alpha-5 (IFNA5) ELISA Kit | Human | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P01569 | RUO | ||
Abbexa | IFNA5 | abx585733 | Low Sample Volume Mouse Interferon Alpha 5 (IFNA5) ELISA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.2 pg/ml | 825 | 96 tests | RUO | |
Abbexa | IFNA5 | abx528088 | Mouse Interferon alpha-5 (IFNA5) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P07349 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | IFNA5 | abx131207 | Interferon Alpha 5 (IFNa5) Antibody | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IFNA5 | abx030316 | Interferon Alpha 5 (IFNA5) Antibody | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNA5) | Unconjugated | ELISA, WB | 281.25 | 80 µl | P01569 | RUO | |
Abbexa | IFNA5 | abx177033 | Interferon Alpha 5 (IFNa5) Antibody | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IFNA5 | abx101880 | Interferon Alpha 5 (IFNa5) Antibody | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IFNA5 | abx131967 | Interferon Alpha 5 (IFNa5) Antibody | Human | Monoclonal | Mouse | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 237.5 | 100 µl | RUO | ||
Abbexa | IFNA5 | abx375425 | Interferon Alpha 5 (IFNA5) Antibody | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNA5) | Unconjugated | ELISA, WB | 337.5 | 100 µg | P01569 | RUO | |
Abbexa | IFNA5 | abx343573 | Interferon alpha-5 (IFNa5) Antibody | Human | Polyclonal | Rabbit | Interferon alpha-5 (IFNa5) | Unconjugated | ELISA, IHC | 250 | 50 µl | P01569 | RUO | |
Abbexa | IFNA5 | abx343574 | Interferon alpha-5 (IFNa5) Antibody (HRP) | Human | Polyclonal | Rabbit | Interferon alpha-5 (IFNa5) | HRP | ELISA | 250 | 50 µl | P01569 | RUO | |
Abbexa | IFNA5 | abx343576 | Interferon alpha-5 (IFNa5) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interferon alpha-5 (IFNa5) | Biotin | ELISA | 250 | 50 µl | P01569 | RUO | |
Abbexa | IFNA5 | abx343575 | Interferon alpha-5 (IFNa5) Antibody (FITC) | Human | Polyclonal | Rabbit | Interferon alpha-5 (IFNa5) | FITC | 250 | 50 µl | P01569 | RUO | ||
Abbexa | IFNA5 | abx272400 | Interferon Alpha 5 (IFNa5) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | IFNA5 | abx129377 | Interferon Alpha 5 (IFNa5) Antibody | Mouse | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P07349 | RUO | |
Abbexa | IFNA5 | abx101881 | Interferon Alpha 5 (IFNa5) Antibody | Rat | Polyclonal | Rabbit | Interferon Alpha 5 (IFNa5) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IFNA5 | abx167391 | Mouse Interferon Alpha 5 (IFNa5) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | IFNA5 | abx167164 | Human Interferon Alpha 5 (IFNa5) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P01569 | RUO |
Abbexa | IFNA5 | abx651509 | Human Interferon Alpha 5 (IFNa5) Protein | Human | Recombinant | 293F cell | Unconjugated | WB, SDS-PAGE | 587.5 | 50 µg | P01569 | RUO |
Abbexa | IFNA5 | abx655687 | Human Interferon Alpha 5 (IFNa5) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 5112.5 | 1 mg | RUO | ||
Abbexa | IFNA5 | abx067334 | Human Interferon Alpha 5 (IFNa5) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 250 | 10 µg | P01569 | RUO |
Abbexa | IFNA5 | abx067335 | Rat Interferon Alpha 5 (IFNa5) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 250 | 10 µg | RUO |
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