Human Interferon Alpha 5 (IFNa5) Protein
247€ (10 µg)
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935106861
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name
Human Interferon Alpha 5 (IFNa5) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167164
tested applications
WB, SDS-PAGE
Description
Interferon Alpha 5 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Alpha 5 (IFNa5) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 52.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu22-Glu189 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01569 |
| Alias | INA5,INFA5,leIF G,IFN-alphaG,IFN-alpha-5,Interferon alpha-61,Interferon alpha-G |
| Background | Protein IFNA5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interferon Alpha 5 (IFNA5) is a member of the type I interferon family and plays a vital role in innate and adaptive immune responses. IFNA5 is secreted by immune cells like dendritic cells, macrophages, and lymphocytes in response to viral infections, double-stranded RNA, or other pathogen-associated molecular patterns (PAMPs). Once released, IFNA5 binds to the interferon-alpha/beta receptor (IFNAR), initiating a signaling cascade through the JAK-STAT pathway. This cascade induces the transcription of interferon-stimulated genes, which activate antiviral, antiproliferative, and immunomodulatory mechanisms. These effects include inhibition of viral replication, increased antigen presentation, and activation of natural killer (NK) cells and cytotoxic T lymphocytes. While not as widely studied as IFNA2, IFNA5 may have tissue-specific or pathogen-specific roles, contributing to its nuanced function within the immune system.
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