Family main features
ntercellular Adhesion Molecule 4 (ICAM-4) is another member of the ICAM family, but with unique functions compared to ICAM-1, ICAM-2, and ICAM-3. ICAM-4, like other ICAMs, is a glycoprotein. It contains two extracellular immunoglobulin-like domains and a short cytoplasmic tail. ICAM-4 is unique among the ICAM family members because it is primarily expressed on red blood cells (erythrocytes). It plays a role in the adhesion of erythrocytes to endothelial cells in the blood vessel walls. ICAM-4 is involved in erythropoiesis, the process of red blood cell production. It is present on erythroblasts and helps in their maturation. By mediating adhesion between red blood cells and endothelial cells, ICAM-4 may have implications for blood flow and vascular function. Changes in ICAM-4 expression or function have been associated with certain blood disorders, such as sickle cell disease. In sickle cell disease, abnormal hemoglobin causes red blood cells to become rigid and sticky, and ICAM-4 has been implicated in the adhesion of these cells to the endothelium. ICAM-4 has also been studied in the context of malaria. Some research suggests that ICAM-4 may be involved in the adhesion of malaria-infected red blood cells to endothelial cells, contributing to the pathogenesis of the disease.
ICAM-4 is one of five members of the ICAM family, which includes ICAM-1, ICAM-2, ICAM-3, ICAM-4, and ICAM-5. These molecules are characterized by their role in cell adhesion and their immunoglobulin-like domain structures.
ICAM-4 plays a crucial role in the adhesion of erythrocytes to other cells and extracellular matrix components. It serves several key functions:
ICAM-4 interacts primarily with integrins, including:
Dysregulation of ICAM-4 expression or function can impact various physiological and pathological processes, including:
ICAM-4 is a vital adhesion molecule expressed on erythrocytes, facilitating their interactions with other cells and extracellular matrix components. It plays a significant role in maintaining blood flow and vessel integrity and can influence immune responses. Understanding ICAM-4's interactions and functions provides insights into its involvement in diseases such as sickle cell disease, malaria, and anemia, highlighting its potential as a therapeutic target for these conditions.
Intercellular adhesion molecule 4 (ICAM4)
Landsteiner Wiener blood group,LW,CD242
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con ICAM4 - Intercellular adhesion molecule 4
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 23 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ICAM4 | abx492874 | Human Intercellular Adhesion Molecule 4 (ICAM4) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ICAM4 | abx151893 | Human Intercellular Adhesion Molecule 4 (ICAM4) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | ICAM4 | abx195984 | Human Intercellular Adhesion Molecule 4 (ICAM4) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 0.625 ng/ml - 40 ng/ml | 0.38 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | ICAM4 | abx250994 | Human Intercellular Adhesion Molecule 4 (ICAM4) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 3.125 ng/ml - 200 ng/ml | 1.88 ng/ml | 525 | 96 tests | Q14773 | RUO |
Abbexa | ICAM4 | abx156943 | Mouse Intercellular Adhesion Molecule 4 (ICAM4) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | ICAM4 | abx492875 | Mouse Intercellular Adhesion Molecule 4 (ICAM4) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | ICAM4 | abx432835 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Goat | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | ICAM4 | abx210846 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx037949 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | ICAM4 | abx320994 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx103617 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx172980 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Monoclonal | Mouse | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | ICAM4 | abx036011 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | BC000046 | RUO | |
Abbexa | ICAM4 | abx113201 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx339550 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx322479 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx006952 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Human | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | WB | 175 | 20 µl | Q14773 | RUO | |
Abbexa | ICAM4 | abx129327 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Mouse | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9ERM2 | RUO | |
Abbexa | ICAM4 | abx103618 | Intercellular Adhesion Molecule 4 (ICAM4) Antibody | Rat | Polyclonal | Rabbit | Intercellular Adhesion Molecule 4 (ICAM4) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ICAM4 | abx067314 | Rat Intercellular Adhesion Molecule 4 (ICAM4) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | D3ZP29 | RUO |
FineTest | ICAM4 | P6576 | Recombinant Human ICAM4 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9BWR0 | RUO | ||
Abbexa | ICAM4 | abx168342 | Mouse Intercellular Adhesion Molecule 4 (ICAM4) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9ERM2 | RUO |
Abbexa | ICAM4 | abx067312 | Human Intercellular Adhesion Molecule 4 (ICAM4) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q14773 | RUO |
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