Human Intercellular Adhesion Molecule 4 (ICAM4) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ICAM4
proveedor
Abbexareference
abx067312Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Intercellular Adhesion Molecule 4 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ICAM4 (Intercellular Adhesion Molecule 4) is a transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily and is primarily expressed on erythrocytes (red blood cells). ICAM4 functions as an adhesion molecule, playing a significant role in cell-to-cell interactions, particularly between red blood cells and other cell types. It is also known as the Landsteiner-Wiener blood group antigen and is encoded by the ICAM4 gene, which is located on chromosome 19. The primary physiological role of ICAM4 is in mediating interactions with other cells, notably endothelial cells, leukocytes, and macrophages, contributing to the cellular processes in circulation and immune response. ICAM4 is part of the ICAM family of molecules, which includes ICAM1, ICAM2, ICAM3, and ICAM5. ICAM molecules are generally involved in leukocyte-endothelial cell adhesion and signaling pathways that regulate inflammation and immune responses. ICAM4, although sharing structural similarities with these other molecules, is unique in its specificity to erythrocytes and its function in erythrocyte interactions, notably through binding with integrins such as α4β1 and αV integrins found on various immune cells.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Intercellular Adhesion Molecule 4 (ICAM4)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.1 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met52-Trp234 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ICAM4
dry ice
No
availability
Shipped within 5-7 working days.
alias
Landsteiner-Wiener blood group,LW,CD242,Landsteiner-Wiener blood group glycoprotein
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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