Intercellular Adhesion Molecule 4 (ICAM4) Antibody

Este producto es parte de ICAM4 - intercellular adhesion molecule 4
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169€ (20 µl)

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935106861
info@markelab.com
name
Intercellular Adhesion Molecule 4 (ICAM4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322479
tested applications
ELISA, WB, IHC

Description

ICAM4 Antibody is a Rabbit Polyclonal against ICAM4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Intercellular Adhesion Molecule 4 (ICAM4)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
20 µl
Size 2
50 µl
Size 3
100 µl
Size 4
200 µl
Size 5
1 ml
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q14773
Gene ID
3386
NCBI Accession
NP_001034221.1, NM_001039132.2, NP_001535.1, NM_001544.4
OMIM
111250
Alias
Landsteiner-Wiener blood group,LW,CD242,Landsteiner-Wiener blood group glycoprotein
Background
Antibody anti-ICAM4
Status
RUO

Descripción

ICAM4 (Intercellular Adhesion Molecule 4) is a transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily and is primarily expressed on erythrocytes (red blood cells). ICAM4 functions as an adhesion molecule, playing a significant role in cell-to-cell interactions, particularly between red blood cells and other cell types. It is also known as the Landsteiner-Wiener blood group antigen and is encoded by the ICAM4 gene, which is located on chromosome 19. The primary physiological role of ICAM4 is in mediating interactions with other cells, notably endothelial cells, leukocytes, and macrophages, contributing to the cellular processes in circulation and immune response. ICAM4 is part of the ICAM family of molecules, which includes ICAM1, ICAM2, ICAM3, and ICAM5. ICAM molecules are generally involved in leukocyte-endothelial cell adhesion and signaling pathways that regulate inflammation and immune responses. ICAM4, although sharing structural similarities with these other molecules, is unique in its specificity to erythrocytes and its function in erythrocyte interactions, notably through binding with integrins such as α4β1 and αV integrins found on various immune cells.

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