Family main features
GULP (Engulfment Adaptor PTB Domain Containing 1) is an adaptor protein involved in cellular processes such as phagocytosis and cell signaling. GULP is a key player in the clearance of apoptotic cells and has been implicated in various developmental and immune processes. The protein is named for its role in mediating the engulfment of apoptotic cells, a critical function for maintaining tissue homeostasis and immune response. GULP interacts with membrane receptors and signaling proteins, thereby linking extracellular signals to intracellular pathways.
GULP is characterized by several functional domains that enable its role in signal transduction and cellular engulfment:
GULP belongs to the family of PTB domain-containing adaptor proteins. While GULP itself is a distinct protein, it shares structural and functional similarities with other adaptor proteins that utilize PTB domains for mediating protein-protein interactions.
GULP plays several critical roles in cellular processes:
Alterations in GULP function or expression can lead to several diseases and disorders:
GULP (Engulfment Adaptor PTB Domain Containing 1) is a crucial adaptor protein involved in phagocytosis and cell signaling. Structurally, GULP features a PTB domain that binds to phosphotyrosine residues, proline-rich regions for SH3 domain interactions, and a C-terminal domain for additional protein interactions. GULP is essential for the engulfment of apoptotic cells, linking receptor activation to downstream signaling pathways. Dysregulation of GULP function is associated with autoimmune diseases, neurodegenerative conditions, developmental disorders, and cancer. Understanding GULP's mechanisms and functions in cellular processes is critical for developing therapeutic strategies for these conditions.
GULP engulfment adaptor PTB domain containing 1 (GULP1)
GULP1,CED6,GULP,CED-6
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | GULP1 | EH9001 | Human GULP1 (PTB domain-containing engulfment adapter protein 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q9UBP9 | RUO | ||
Abbexa | GULP1 | abx387723 | Human PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q9UBP9 | RUO |
Abbexa | GULP1 | abx389492 | Mouse PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q8K2A1 | RUO |
Abbexa | GULP1 | abx391427 | Rat PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q5PQS4 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | GULP1 | FNab03732 | anti- GULP1 antibody | human | polyclonal | Rabbit | GULP, engulfment adaptor PTB domain containing 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx316608 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody (Biotin) | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Biotin | ELISA | 162.5 | 20 µg | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx316607 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody (FITC) | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | FITC | 162.5 | 20 µg | Q9UBP9 | RUO | ||
Abbexa | GULP1 | abx430456 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody | Human | Polyclonal | Goat | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | GULP1 | abx316606 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody (HRP) | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | HRP | ELISA | 162.5 | 20 µg | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx112912 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx002461 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Unconjugated | WB, IHC | 175 | 20 µl | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx233732 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9UBP9 | RUO | |
Abbexa | GULP1 | abx318832 | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody | Human | Polyclonal | Rabbit | PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) | Unconjugated | ELISA, WB, IF/ICC | 162.5 | 20 µg | Q9UBP9 | RUO |
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