GULP1 antibody
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Name
GULP1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab03732
Tested Applications
ELISA, WB, IHC
Description
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | GULP, engulfment adaptor PTB domain containing 1 (GULP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UBP9 |
| Gene ID | 51454 |
| Alias | GULP1,CED6,GULP,CED-6 |
| Background | Antibody anti-GULP1 |
| Status | RUO |
| Note | Mol. Weight 45 kDa |
Background
GULP1 is an adaptor protein containing a phosphotyrosine-binding (PTB) domain that mediates signal transduction in cell engulfment, phagocytosis, and apoptotic cell clearance. It interacts with transmembrane receptors like integrins and members of the engulfment pathway, including the CED-1 homologs. GULP1 facilitates actin cytoskeletal rearrangement by bridging receptors to downstream signaling proteins during phagosome formation. It is essential for apoptotic cell removal and has roles in cell migration and lipid homeostasis. GULP1 is expressed in macrophages, epithelial cells, and neurons, where it regulates tissue remodeling and cellular debris clearance. Dysregulation is linked to impaired phagocytosis, inflammatory diseases, and neurodegenerative disorders. Studies in knockout models highlight its role in maintaining immune homeostasis and preventing chronic inflammation.
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