Mouse PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GULP1
proveedor
Abbexareference
abx389492Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse GULP1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GULP1 is an adaptor protein containing a phosphotyrosine-binding (PTB) domain that mediates signal transduction in cell engulfment, phagocytosis, and apoptotic cell clearance. It interacts with transmembrane receptors like integrins and members of the engulfment pathway, including the CED-1 homologs. GULP1 facilitates actin cytoskeletal rearrangement by bridging receptors to downstream signaling proteins during phagosome formation. It is essential for apoptotic cell removal and has roles in cell migration and lipid homeostasis. GULP1 is expressed in macrophages, epithelial cells, and neurons, where it regulates tissue remodeling and cellular debris clearance. Dysregulation is linked to impaired phagocytosis, inflammatory diseases, and neurodegenerative disorders. Studies in knockout models highlight its role in maintaining immune homeostasis and preventing chronic inflammation.
Características del producto
category
ELISA Kits
immunogen target
PTB Domain Containing Engulfment Adapter Protein 1 (GULP1)
reactivity
Mouse
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GULP1,CED6,GULP,CED-6
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GULP1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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