FNIP - folliculin interacting protein | Elisa - Clia - Antibody - Protein

Family main features

Background

Folliculin Interacting Proteins (FNIPs), including FNIP1 and FNIP2, are essential components of the cellular machinery that interact with the protein folliculin (FLCN). These proteins are encoded by the FNIP1 and FNIP2 genes, respectively. They play a critical role in regulating energy homeostasis, cellular metabolism, and the mTOR (mechanistic target of rapamycin) signaling pathway, which is crucial for cell growth and survival. FNIP1 and FNIP2 were initially identified due to their interaction with folliculin, a tumor suppressor protein mutated in Birt-Hogg-Dubé syndrome.


Protein Structure

FNIP1 and FNIP2 are large proteins, approximately 1,200-1,300 amino acids in length. They share significant structural similarity and are characterized by several important domains:


  • Coiled-coil domains: Facilitate protein-protein interactions, critical for binding to folliculin.
  • Conserved regions: Enable interaction with other regulatory proteins such as AMPK (AMP-activated protein kinase).
  • C-terminal domain: Essential for the stability and function of the protein in cellular processes. The structural integrity of FNIP proteins is vital for their role in cellular signaling and metabolic regulation.


Classification and Subtypes

FNIP proteins are classified primarily based on their interaction with FLCN and their involvement in metabolic regulation:


  • FNIP1: The first identified interacting partner of FLCN, playing a major role in AMPK and mTOR signaling pathways.
  • FNIP2: Shares a high degree of homology with FNIP1 and performs similar functions in cellular metabolism and energy homeostasis. Both proteins are ubiquitously expressed, with higher expression in tissues with high metabolic activity.


Function and Biological Significance

FNIP proteins are crucial for several cellular functions:


  • Regulation of mTOR Signaling: FNIP1 and FNIP2 modulate mTORC1 activity, influencing cell growth and proliferation.
  • Energy Homeostasis: By interacting with AMPK, FNIP proteins help maintain cellular energy balance under varying metabolic conditions.
  • Autophagy and Stress Response: FNIPs are involved in the cellular response to nutrient deprivation and other stresses, promoting autophagy and survival.
  • Tumor Suppression: Through their interaction with FLCN, FNIP proteins play a role in preventing uncontrolled cell growth and tumor formation. The regulatory functions of FNIPs highlight their importance in maintaining cellular homeostasis and preventing metabolic disorders.


Clinical Issues

Dysregulation of FNIP proteins has been implicated in several clinical conditions:


  • Birt-Hogg-Dubé Syndrome: Mutations in FLCN, and by extension disruptions in FNIP interactions, lead to this syndrome characterized by skin lesions, pulmonary cysts, and renal tumors.
  • Cancer: Aberrations in FNIP expression or function are associated with various cancers, due to their role in cell growth and proliferation regulation.
  • Metabolic Disorders: Given their role in energy homeostasis, disruptions in FNIP function can contribute to metabolic syndromes and related diseases.


Summary

Folliculin Interacting Proteins, FNIP1 and FNIP2, are critical components in the regulation of cellular metabolism and energy balance. These proteins interact with folliculin to modulate key signaling pathways such as mTOR and AMPK. Structural features like coiled-coil domains and conserved regions are essential for their function. Dysregulation of FNIP proteins is linked to Birt-Hogg-Dubé syndrome, various cancers, and metabolic disorders. Understanding the function and regulation of FNIP proteins provides valuable insights into potential therapeutic targets for these conditions.



FNIP1 Recommended name:

folliculin interacting protein 1 (FNIP1)

Aliases for FNIP1

IMD93,KIAA1961

FNIP2 Recommended name:

folliculin interacting protein 2 (FNIP2)

Aliases for FNIP2

FNIPL,MAPO1,KIAA1450,FNIP1-like protein,O6-methylguanine-induced apoptosis 1 protein

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con FNIP - folliculin interacting protein 

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 22 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
FineTestFNIP1EH8566Human FNIP1(Folliculin-interacting protein 1) ELISA KithumanBusacar en las instruccionesSandwich ELISA, Double Antibody0.156-10ng/ml96TQ8TF40RUO
AbbexaFNIP1abx387393Human Folliculin Interacting Protein 1 (FNIP1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.1 ng/ml71596 testsQ8TF40RUO
AbbexaFNIP2abx524105Human Folliculin-interacting protein 2 (FNIP2) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9P278RUO
AbbexaFNIP1abx524104Mouse Folliculin-interacting protein 1 (FNIP1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ68FD7RUO
AbbexaFNIP2abx524106Mouse Folliculin-interacting protein 2 (FNIP2) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ80TD3RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaFNIP1abx432703Folliculin Interacting Protein 1 (FNIP1) AntibodyPolyclonalGoatFolliculin Interacting Protein 1 (FNIP1)UnconjugatedP-ELISA250200 µlRUO
FineTestFNIP1FNab03179anti- FNIP1 antibodyhumanpolyclonalRabbitfolliculin interacting protein 1IgGUnconjugatedELISA, IHC100µgQ8TF40RUO
AbbexaFNIP1abx313612Folliculin Interacting Protein 1 (FNIP1) Antibody (HRP)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)HRPELISA162.520 µgQ8TF40RUO
AbbexaFNIP1abx313611Folliculin Interacting Protein 1 (FNIP1) AntibodyHumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)UnconjugatedELISA, IHC, IF/ICC162.520 µgQ8TF40RUO
AbbexaFNIP1abx313614Folliculin Interacting Protein 1 (FNIP1) Antibody (Biotin)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)BiotinELISA162.520 µgQ8TF40RUO
AbbexaFNIP1abx313613Folliculin Interacting Protein 1 (FNIP1) Antibody (FITC)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)FITC162.520 µgQ8TF40RUO
AbbexaFNIP1abx447824Folliculin Interacting Protein 1 (FNIP1) Antibody (PerCP)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)PerCPWB, IHC, IF/ICC612.5100 µgQ8TF40RUO
AbbexaFNIP1abx447820Folliculin Interacting Protein 1 (FNIP1) Antibody (Biotin)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)BiotinWB, IHC, IF/ICC600100 µgQ8TF40RUO
AbbexaFNIP1abx447825Folliculin Interacting Protein 1 (FNIP1) Antibody (PE)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)PEWB, IHC, IF/ICC612.5100 µgQ8TF40RUO
AbbexaFNIP1abx447821Folliculin Interacting Protein 1 (FNIP1) Antibody (FITC)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)FITCWB, IHC, IF/ICC600100 µgQ8TF40RUO
AbbexaFNIP1abx447822Folliculin Interacting Protein 1 (FNIP1) Antibody (HRP)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)HRPWB, IHC, IF/ICC600100 µgQ8TF40RUO
AbbexaFNIP1abx448561Folliculin Interacting Protein 1 (FNIP1) AntibodyHumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)UnconjugatedWB, IHC, IF/ICC550100 µgQ8TF40RUO
AbbexaFNIP1abx447813Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO594)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)ATTO594WB, IHC, IF/ICC612.5100 µgQ8TF40RUO
AbbexaFNIP1abx447819Folliculin Interacting Protein 1 (FNIP1) Antibody (APC)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)APCWB, IHC, IF/ICC612.5100 µgQ8TF40RUO
AbbexaFNIP1abx233179Folliculin Interacting Protein 1 (FNIP1) AntibodyHumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)UnconjugatedELISA, IHC350100 µgQ8TF40RUO
AbbexaFNIP1abx447810Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO390)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)ATTO390WB, IHC, IF/ICC612.5100 µgQ8TF40RUO
AbbexaFNIP1abx447811Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO488)HumanPolyclonalRabbitFolliculin Interacting Protein 1 (FNIP1)ATTO488WB, IHC, IF/ICC612.5100 µgQ8TF40RUO

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