FNIP - folliculin interacting protein | Elisa - Clia - Antibody - Protein
Family main features
Background
Folliculin Interacting Proteins (FNIPs), including FNIP1 and FNIP2, are essential components of the cellular machinery that interact with the protein folliculin (FLCN). These proteins are encoded by the FNIP1 and FNIP2 genes, respectively. They play a critical role in regulating energy homeostasis, cellular metabolism, and the mTOR (mechanistic target of rapamycin) signaling pathway, which is crucial for cell growth and survival. FNIP1 and FNIP2 were initially identified due to their interaction with folliculin, a tumor suppressor protein mutated in Birt-Hogg-Dubé syndrome.
Protein Structure
FNIP1 and FNIP2 are large proteins, approximately 1,200-1,300 amino acids in length. They share significant structural similarity and are characterized by several important domains:
- Coiled-coil domains: Facilitate protein-protein interactions, critical for binding to folliculin.
- Conserved regions: Enable interaction with other regulatory proteins such as AMPK (AMP-activated protein kinase).
- C-terminal domain: Essential for the stability and function of the protein in cellular processes. The structural integrity of FNIP proteins is vital for their role in cellular signaling and metabolic regulation.
Classification and Subtypes
FNIP proteins are classified primarily based on their interaction with FLCN and their involvement in metabolic regulation:
- FNIP1: The first identified interacting partner of FLCN, playing a major role in AMPK and mTOR signaling pathways.
- FNIP2: Shares a high degree of homology with FNIP1 and performs similar functions in cellular metabolism and energy homeostasis. Both proteins are ubiquitously expressed, with higher expression in tissues with high metabolic activity.
Function and Biological Significance
FNIP proteins are crucial for several cellular functions:
- Regulation of mTOR Signaling: FNIP1 and FNIP2 modulate mTORC1 activity, influencing cell growth and proliferation.
- Energy Homeostasis: By interacting with AMPK, FNIP proteins help maintain cellular energy balance under varying metabolic conditions.
- Autophagy and Stress Response: FNIPs are involved in the cellular response to nutrient deprivation and other stresses, promoting autophagy and survival.
- Tumor Suppression: Through their interaction with FLCN, FNIP proteins play a role in preventing uncontrolled cell growth and tumor formation. The regulatory functions of FNIPs highlight their importance in maintaining cellular homeostasis and preventing metabolic disorders.
Clinical Issues
Dysregulation of FNIP proteins has been implicated in several clinical conditions:
- Birt-Hogg-Dubé Syndrome: Mutations in FLCN, and by extension disruptions in FNIP interactions, lead to this syndrome characterized by skin lesions, pulmonary cysts, and renal tumors.
- Cancer: Aberrations in FNIP expression or function are associated with various cancers, due to their role in cell growth and proliferation regulation.
- Metabolic Disorders: Given their role in energy homeostasis, disruptions in FNIP function can contribute to metabolic syndromes and related diseases.
Summary
Folliculin Interacting Proteins, FNIP1 and FNIP2, are critical components in the regulation of cellular metabolism and energy balance. These proteins interact with folliculin to modulate key signaling pathways such as mTOR and AMPK. Structural features like coiled-coil domains and conserved regions are essential for their function. Dysregulation of FNIP proteins is linked to Birt-Hogg-Dubé syndrome, various cancers, and metabolic disorders. Understanding the function and regulation of FNIP proteins provides valuable insights into potential therapeutic targets for these conditions.
FNIP1 Recommended name:
folliculin interacting protein 1 (FNIP1)
Aliases for FNIP1
IMD93,KIAA1961
FNIP2 Recommended name:
folliculin interacting protein 2 (FNIP2)
Aliases for FNIP2
FNIPL,MAPO1,KIAA1450,FNIP1-like protein,O6-methylguanine-induced apoptosis 1 protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con FNIP - folliculin interacting protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 22 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | FNIP1 | EH8566 | Human FNIP1(Folliculin-interacting protein 1) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q8TF40 | RUO | ||
Abbexa | FNIP1 | abx387393 | Human Folliculin Interacting Protein 1 (FNIP1) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.1 ng/ml | 715 | 96 tests | Q8TF40 | RUO |
Abbexa | FNIP2 | abx524105 | Human Folliculin-interacting protein 2 (FNIP2) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q9P278 | RUO | ||
Abbexa | FNIP1 | abx524104 | Mouse Folliculin-interacting protein 1 (FNIP1) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q68FD7 | RUO | ||
Abbexa | FNIP2 | abx524106 | Mouse Folliculin-interacting protein 2 (FNIP2) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q80TD3 | RUO |
Primary Antibodies
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FNIP1 | abx432703 | Folliculin Interacting Protein 1 (FNIP1) Antibody | Polyclonal | Goat | Folliculin Interacting Protein 1 (FNIP1) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
FineTest | FNIP1 | FNab03179 | anti- FNIP1 antibody | human | polyclonal | Rabbit | folliculin interacting protein 1 | IgG | Unconjugated | ELISA, IHC | 100µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx313612 | Folliculin Interacting Protein 1 (FNIP1) Antibody (HRP) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | HRP | ELISA | 162.5 | 20 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx313611 | Folliculin Interacting Protein 1 (FNIP1) Antibody | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx313614 | Folliculin Interacting Protein 1 (FNIP1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | Biotin | ELISA | 162.5 | 20 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx313613 | Folliculin Interacting Protein 1 (FNIP1) Antibody (FITC) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | FITC | 162.5 | 20 µg | Q8TF40 | RUO | ||
Abbexa | FNIP1 | abx447824 | Folliculin Interacting Protein 1 (FNIP1) Antibody (PerCP) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | PerCP | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447820 | Folliculin Interacting Protein 1 (FNIP1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | Biotin | WB, IHC, IF/ICC | 600 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447825 | Folliculin Interacting Protein 1 (FNIP1) Antibody (PE) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | PE | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447821 | Folliculin Interacting Protein 1 (FNIP1) Antibody (FITC) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | FITC | WB, IHC, IF/ICC | 600 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447822 | Folliculin Interacting Protein 1 (FNIP1) Antibody (HRP) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | HRP | WB, IHC, IF/ICC | 600 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx448561 | Folliculin Interacting Protein 1 (FNIP1) Antibody | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | Unconjugated | WB, IHC, IF/ICC | 550 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447813 | Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO594) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | ATTO594 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447819 | Folliculin Interacting Protein 1 (FNIP1) Antibody (APC) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | APC | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx233179 | Folliculin Interacting Protein 1 (FNIP1) Antibody | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | Unconjugated | ELISA, IHC | 350 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447810 | Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO390) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | ATTO390 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO | |
Abbexa | FNIP1 | abx447811 | Folliculin Interacting Protein 1 (FNIP1) Antibody (ATTO488) | Human | Polyclonal | Rabbit | Folliculin Interacting Protein 1 (FNIP1) | ATTO488 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q8TF40 | RUO |
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