Human Folliculin-interacting protein 2 (FNIP2) ELISA Kit

Product specifications

ELISA Kits

Folliculin-interacting protein 2 (FNIP2)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q9P278

FNIPL,MAPO1,KIAA1450,FNIP1-like protein,O6-methylguanine-induced apoptosis 1 protein

Elisa kits for FNIP2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

FNIP2, a homolog of FNIP1, functions as a secondary but critical binding partner of folliculin (FCLN) in metabolic regulation and energy sensing. Like FNIP1, FNIP2 contributes to the stability of the FCLN-FNIP complex and facilitates the proper localization and activation of mTORC1 signaling in response to nutrient availability. FNIP2 has overlapping roles with FNIP1, including interactions with AMPK and Hsp90, highlighting its importance in maintaining cellular energy balance. Its expression patterns are similar to FNIP1, being prominent in tissues with high metabolic demand, such as skeletal muscle, kidney, and liver. Studies suggest that FNIP2 may have redundant or compensatory functions with FNIP1, as loss of FNIP2 alone has less severe phenotypic consequences compared to combined FNIP1/FNIP2 deficiencies. FNIP2's role in immune cell metabolism and its involvement in B-cell differentiation suggest potential implications in immune regulation. Despite functional overlap, FNIP2 exhibits unique roles in specific tissues and under stress conditions, emphasizing its distinct but complementary contributions to folliculin-mediated pathways.

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