Mouse Folliculin-interacting protein 1 (FNIP1) ELISA Kit

Este producto es parte de FNIP - folliculin interacting protein 
Product Graph
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Folliculin-interacting protein 1 (FNIP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx524104
tested applications
ELISA

Description

Mouse Folliculin-interacting protein 1 (FNIP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Folliculin-interacting protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Folliculin-interacting protein 1 (FNIP1)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q68FD7
Gene ID
216742
Alias
IMD93,KIAA1961
Background
Elisa kits for FNIP1
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

FNIP1 is a critical binding partner of folliculin (FCLN) and plays a key role in energy sensing and metabolic regulation through its interactions with AMPK and mTOR signaling pathways. FNIP1 acts as a molecular scaffold, facilitating the assembly of the FCLN-FNIP complex on lysosomal membranes, which is necessary for proper mTORC1 activation in response to nutrient and energy cues. FNIP1 also interacts with the Hsp90 chaperone system, regulating the stability and functionality of FCLN. Loss of FNIP1 impairs AMPK signaling, disrupting cellular energy homeostasis and leading to metabolic dysregulation. Studies in mouse models have shown that FNIP1 is essential for B-cell development, suggesting a broader role in lymphocyte function and immune responses. FNIP1 expression is highest in metabolically active tissues, including the heart, skeletal muscle, and kidney. Its role in coordinating FCLN function and metabolic signaling positions FNIP1 as a key regulator of cellular growth and proliferation, and its dysregulation is implicated in oncogenic and metabolic disorders.

Related Products

EH8566

Human FNIP1 (Folliculin-interacting protein 1) ELISA Kit

Ver Producto
FNab03179

FNIP1 antibody

May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Ver Producto
abx233179

Folliculin Interacting Protein 1 (FNIP1) Antibody

FNIP1 Antibody is a Rabbit Polyclonal against FNIP1.

Ver Producto