Family main features
Fibroblast Growth Factor Receptor 3 (FGFR3) is a member of the FGFR family, which consists of four known receptors (FGFR1 to FGFR4). These receptors are part of the larger tyrosine kinase receptor family that binds to fibroblast growth factors (FGFs). FGFR3 plays a crucial role in various biological processes, including cell growth, differentiation, and regulation of skeletal development. The FGFR3 gene is located on chromosome 4p16.3, and its expression is essential for normal skeletal development and maintenance. Mutations in FGFR3 are associated with several skeletal dysplasias and cancer pathogenesis.
FGFR3 is primarily expressed in cartilage, brain, kidney, and intestines, indicating its diverse role in different tissues. The receptor's expression and activity are tightly regulated to ensure proper cellular functions and development. Aberrations in FGFR3 signaling can lead to severe developmental disorders and contribute to oncogenesis.
FGFR3 is a transmembrane protein comprising several distinct domains that facilitate its function:
FGFR3 belongs to the FGFR family, which includes FGFR1, FGFR2, FGFR3, and FGFR4. FGFR3 itself has several isoforms due to alternative splicing, with the major ones being FGFR3 IIIb and FGFR3 IIIc. These isoforms differ in their ligand-binding specificities and tissue distribution:
The diversity in isoforms allows FGFR3 to participate in a wide range of biological processes and ensures precise regulation of cellular activities in different tissue types.
FGFR3 mediates numerous cellular functions through its interaction with FGFs and activation of intracellular signaling pathways. Key functions of FGFR3 include:
Mutations and dysregulation of FGFR3 are associated with several clinical conditions:
FGFR3 is a critical receptor in the FGFR family, essential for regulating skeletal development and cellular functions in various tissues. Its structure, characterized by distinct extracellular, transmembrane, and intracellular domains, enables it to mediate diverse biological processes through interactions with FGFs. The receptor's isoforms, FGFR3 IIIb and FGFR3 IIIc, expand its functional versatility by binding different FGFs and exhibiting varied tissue distributions.
Clinically, FGFR3 is significant due to its association with skeletal dysplasias and various cancers. Understanding the molecular mechanisms of FGFR3 signaling and its pathological alterations provides insights into potential therapeutic strategies. As research progresses, FGFR3-targeted therapies hold promise for treating conditions resulting from its dysregulation, highlighting the receptor's importance in both health and disease.
fibroblast growth factor receptor 3 (FGFR3)
ACH,CEK2,JTK4,CD333,FGFR-3
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con FGFR3 - fibroblast growth factor receptor 3
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 31 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | FGFR3 | abx355585 | Chicken Fibroblast Growth Factor Receptor 3 (FGFR3) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | FGFR3 | abx151532 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | FGFR3 | abx252458 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 493.75 | 96 tests | P22607 | RUO |
Abbexa | FGFR3 | abx195040 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | FGFR3 | abx493094 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | FGFR3 | abx154016 | Mouse Fibroblast Growth Factor Receptor 3 (FGFR3) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 675 | 96 tests | RUO | |
Abbexa | FGFR3 | abx493095 | Mouse Fibroblast Growth Factor Receptor 3 (FGFR3) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | FGFR3 | FNab10801 | anti- FGFR3 antibody | human | polyclonal | Rabbit | fibroblast growth factor receptor 3 | IgG | Unconjugated | ELISA, WB | 100µg | P22607 | RUO | |
Abbexa | FGFR3 | abx402287 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Monoclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, IF/ICC | 287.5 | 50 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx033562 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx109787 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx106838 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody (FITC) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | FITC | 162.5 | 20 µg | P22607 | RUO | ||
Abbexa | FGFR3 | abx402559 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Monoclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, WB | 287.5 | 50 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx105419 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Biotin | ELISA | 162.5 | 20 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx016160 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Monoclonal | Mouse | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA | 362.5 | 100 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx172424 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Monoclonal | Mouse | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | FGFR3 | abx224151 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Monoclonal | Mouse | Fibroblast Growth Factor Receptor 3 (FGFR3) | ELISA, IHC, FCM | 362.5 | 100 µl | P22607 | RUO | ||
Abbexa | FGFR3 | abx103827 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx108258 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody (HRP) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | HRP | ELISA | 162.5 | 20 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx028350 | Fibroblast Growth Factor Receptor 3 (Fgfr3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (Fgfr3) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q61851 | RUO | |
Abbexa | FGFR3 | abx010779 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, WB | 350 | 100 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx213604 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx135701 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | P22607 | RUO | |
Abbexa | FGFR3 | abx328380 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx013077 | Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 3 (FGFR3) | Unconjugated | WB, IHC | 43.75 | 10 µg | P22607 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FGFR3 | abx653417 | Mouse Fibroblast Growth Factor Receptor 3 (FGFR3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | FGFR3 | abx066614 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P22607 | RUO |
Abbexa | FGFR3 | abx073880 | Human Fibroblast Growth Factor Receptor 3 (FGFR3) Protein | Human | Recombinant | Insect | SDS-PAGE | 225 | 2 µg | P22607 | RUO | |
Abbexa | FGFR3 | abx169305 | Human Fibroblast Growth Factor Receptor 3b (FGFR3b) Protein | Human | Recombinant | HEK293 cells | Unconjugated | WB | 162.5 | 10 µg | P22607-2 | RUO |
Abbexa | FGFR3 | abx169306 | Human Fibroblast Growth Factor Receptor 3c (FGFR3c) Protein | Human | Recombinant | HEK293 cells | Unconjugated | WB | 162.5 | 10 µg | P22607-1 | RUO |
FineTest | FGFR3 | P1531 | Recombinant Human FGFR3 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P22607 | RUO |
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