FGFR3 Cell ELISA Kit
513.5€ (96 tests)
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name
FGFR3 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595226
tested applications
ELISA
Description
FGFR3 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | FGFR3 |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P22607 |
| Gene ID | 2261 |
| OMIM | 134934 |
| Alias | ACH,CEK2,JTK4,CD333,FGFR-3 |
| Background | Elisa kits for FGFR3 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Fibroblast growth factor receptor 3 (FGFR3) FGFR3 is a transmembrane tyrosine kinase receptor that mediates fibroblast growth factor (FGF) signaling, playing critical roles in skeletal development, cartilage maintenance, and cell proliferation. Structurally, FGFR3 comprises an extracellular ligand-binding domain with three immunoglobulin-like loops, a single transmembrane domain, and an intracellular kinase domain that transduces signals upon ligand-induced dimerization and autophosphorylation. FGFR3 is highly expressed in cartilage, where it regulates chondrocyte differentiation and proliferation. Gain-of-function mutations in FGFR3 are associated with skeletal dysplasias such as achondroplasia and thanatophoric dysplasia, characterized by impaired bone growth due to excessive inhibition of chondrocyte proliferation. Additionally, FGFR3 is implicated in cancer, including bladder cancer and multiple myeloma, where aberrant activation of FGFR3 signaling promotes cell proliferation and survival. FGFR3’s regulatory roles in growth plate development and oncogenesis highlight its dual importance in development and disease pathology.
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