Human Fibroblast Growth Factor Receptor 3b (FGFR3b) Protein
182€ (10 µg)
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Name
Human Fibroblast Growth Factor Receptor 3b (FGFR3b) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx169305
Tested Applications
SDS-PAGE, WB
Description
Human Fibroblast Growth Factor Receptor 3 (FGFR3b) Protein is a recombinant protein produced in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor 3b (FGFR3b) |
| Host | HEK293 cells |
| Assay Type | Sequence Fragment: 23-377 AA (Isoform 2). Tag: C-terminal 10 His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 41.2 kDa Observed MW (SDS-PAGE): 55 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE, WB |
| Buffer | PBS, containing 20% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Storage: Aliquot and store between -20 °C and -80°C. Avoid repeated freeze/thaw cycles. Stability: Stable for at least 1 month when stored between 2°C and 8°C, or for at least 12 months when stored between -20°C and -80°C. |
| Dry Ice | No |
| UniProt ID | P22607-2 |
| Gene ID | 2261 |
| OMIM | 100800 |
| Alias | ACH,CEK2,JTK4,CD333,FGFR-3 |
| Background | Protein FGFR3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 0.1 ng/µg (1 IEU/µg), as measured by LAL method. |
Background
Fibroblast growth factor receptor 3 (FGFR3) FGFR3 is a transmembrane tyrosine kinase receptor that mediates fibroblast growth factor (FGF) signaling, playing critical roles in skeletal development, cartilage maintenance, and cell proliferation. Structurally, FGFR3 comprises an extracellular ligand-binding domain with three immunoglobulin-like loops, a single transmembrane domain, and an intracellular kinase domain that transduces signals upon ligand-induced dimerization and autophosphorylation. FGFR3 is highly expressed in cartilage, where it regulates chondrocyte differentiation and proliferation. Gain-of-function mutations in FGFR3 are associated with skeletal dysplasias such as achondroplasia and thanatophoric dysplasia, characterized by impaired bone growth due to excessive inhibition of chondrocyte proliferation. Additionally, FGFR3 is implicated in cancer, including bladder cancer and multiple myeloma, where aberrant activation of FGFR3 signaling promotes cell proliferation and survival. FGFR3’s regulatory roles in growth plate development and oncogenesis highlight its dual importance in development and disease pathology.
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