Family main features
Toll-like receptor 6 (TLR6) is a pattern-recognition receptor (PRR) in the toll-like receptor family that plays a critical role in the innate immune system. It is highly conserved across many species and primarily recognizes microbial components, particularly diacylated lipopeptides, which are lipid molecules derived from pathogens such as Gram-positive bacteria and certain fungi. TLR6 forms heterodimers with TLR2 to recognize these microbial products, allowing the immune system to detect the presence of pathogens and initiate a rapid immune response.
TLR6 is expressed in various immune cells, including macrophages, dendritic cells, monocytes, neutrophils, and certain epithelial cells. Activation of TLR6 initiates downstream signaling cascades that promote the production of pro-inflammatory cytokines and chemokines, thereby coordinating immune responses and recruiting additional immune cells to the site of infection. This receptor also plays a role in tissue repair, and recent studies suggest its involvement in some chronic inflammatory and autoimmune diseases, as well as potential links to cancer. Understanding TLR6’s mechanisms and structure is essential for designing therapeutics that can modulate immune responses in a range of diseases.
TLR6, like other toll-like receptors, is a type I transmembrane protein with approximately 796 amino acids. It is structurally organized into three primary domains: an extracellular domain, a transmembrane domain, and an intracellular Toll/IL-1 receptor (TIR) domain. Each of these domains has distinct structural features that contribute to TLR6’s functional capabilities.
Extracellular Domain:
Transmembrane Domain:
Intracellular (TIR) Domain:
TLR6 is classified within the toll-like receptor (TLR) family, specifically as part of the TLR1 subfamily due to its sequence similarity and functional interactions with TLR2. TLR6 does not have subtypes or isoforms with distinct functions but relies on its ability to form heterodimers, primarily with TLR2, to recognize specific pathogen-associated molecular patterns (PAMPs). In the presence of diacylated lipopeptides, TLR6 preferentially partners with TLR2 rather than TLR1, allowing it to detect a different subset of microbial molecules compared to the TLR2/TLR1 heterodimer, which generally binds triacylated lipopeptides.
TLR6 plays an essential role in detecting bacterial and fungal infections by recognizing components specific to these pathogens. Its functions include:
Pathogen Recognition:
Signaling Pathways:
Role in Inflammation and Immune Response:
Homeostasis and Tissue Repair:
Dysregulation of TLR6 signaling can lead to various clinical issues due to either excessive or insufficient immune responses:
Chronic Inflammatory Diseases:
Autoimmune Disorders:
Cancer:
Therapeutic Targeting:
TLR6 is a critical component of the innate immune system, with a specific role in detecting diacylated lipopeptides from Gram-positive bacteria and fungi through heterodimer formation with TLR2. Its structure, which includes an LRR-rich extracellular domain for ligand recognition and a TIR domain for intracellular signaling, enables it to initiate a robust immune response by activating the MyD88-dependent pathway. This pathway triggers pro-inflammatory signaling cascades, including the activation of NF-κB and MAP kinase pathways, leading to cytokine production and recruitment of immune cells.
Clinically, TLR6 is involved in various inflammatory diseases, autoimmune disorders, and cancer. Dysregulated TLR6 signaling can exacerbate conditions like asthma, cardiovascular disease, and autoimmune pathologies, while in cancer, it may either support or inhibit tumor progression, depending on the context. TLR6 remains a promising therapeutic target, with research focusing on manipulating its signaling pathways to control inflammation, enhance immunity, and potentially treat cancers.
toll like receptor 6 (TLR6)
Toll-like receptor 6,CD286
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con TLR6 - toll like receptor 6
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 26 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR6 | abx513697 | Cow Toll Like Receptor 6 (TLR6) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q704V6 | RUO | ||
Abbexa | TLR6 | abx491878 | Human Toll Like Receptor 6 (TLR6) CLIA Kit | Human | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.117 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR6 | abx153346 | Human Toll Like Receptor 6 (TLR6) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 618.75 | 96 tests | RUO | |
FineTest | TLR6 | EM0437 | Mouse TLR6(Toll-like receptor 6) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q9EPW9 | RUO | ||
Abbexa | TLR6 | abx491879 | Mouse Toll Like Receptor 6 (TLR6) CLIA Kit | Mouse | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.54 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR6 | abx154787 | Mouse Toll Like Receptor 6 (TLR6) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.54 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR6 | abx353933 | Rat Toll Like Receptor 6 (TLR6) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 587.5 | 96 tests | Q6P690 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR6 | FNab08729 | anti- TLR6 antibody | human | polyclonal | Rabbit | toll-like receptor 6 | IgG | Unconjugated | ELISA, WB | 100µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx411794 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | WB, IHC | 437.5 | 100 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx305554 | Toll-Like Receptor 6 (TLR6) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | FITC | 162.5 | 20 µg | Q9Y2C9 | RUO | ||
Abbexa | TLR6 | abx210904 | Toll Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx028483 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx339249 | Toll Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx339408 | Toll Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx305555 | Toll-Like Receptor 6 (TLR6) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Biotin | ELISA | 162.5 | 20 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx305553 | Toll-Like Receptor 6 (TLR6) Antibody (HRP) | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | HRP | ELISA | 162.5 | 20 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx174843 | Toll Like Receptor 6 (TLR6) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 6 (TLR6) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | TLR6 | abx302746 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx102074 | Toll Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx005725 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx238729 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx028484 | Toll-Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 6 (TLR6) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | Q9EPW9 | RUO | |
Abbexa | TLR6 | abx326824 | Toll Like Receptor 6 (TLR6) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | Q9Y2C9 | RUO | |
Abbexa | TLR6 | abx102075 | Toll Like Receptor 6 (TLR6) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 6 (TLR6) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9EPW9 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR6 | abx069372 | Mouse Toll Like Receptor 6 (TLR6) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9EPW9 | RUO |
Abbexa | TLR6 | abx069371 | Human Toll Like Receptor 6 (TLR6) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9Y2C9 | RUO |
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