Mouse Toll Like Receptor 6 (TLR6) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Recombinant Toll Like Receptor 6 (TLR6) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Toll Like Receptor 6 (TLR6) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala17-Met239 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9EPW9 |
| Alias | Toll-like receptor 6,CD286 |
| Background | Protein TLR6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Toll-like receptor 6 (TLR6) is a pattern-recognition receptor (PRR) in the toll-like receptor family that plays a critical role in the innate immune system. It is highly conserved across many species and primarily recognizes microbial components, particularly diacylated lipopeptides, which are lipid molecules derived from pathogens such as Gram-positive bacteria and certain fungi. TLR6 forms heterodimers with TLR2 to recognize these microbial products, allowing the immune system to detect the presence of pathogens and initiate a rapid immune response. TLR6 is expressed in various immune cells, including macrophages, dendritic cells, monocytes, neutrophils, and certain epithelial cells. Activation of TLR6 initiates downstream signaling cascades that promote the production of pro-inflammatory cytokines and chemokines, thereby coordinating immune responses and recruiting additional immune cells to the site of infection. This receptor also plays a role in tissue repair, and recent studies suggest its involvement in some chronic inflammatory and autoimmune diseases, as well as potential links to cancer. Understanding TLR6’s mechanisms and structure is essential for designing therapeutics that can modulate immune responses in a range of diseases.
Related Products
Mouse TLR6(Toll-like receptor 6) ELISA Kit
Ver Producto
anti- TLR6 antibody
Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides(PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD(MALP-2), soluble tuberculosis factor(STF), phenol-soluble modulin(PSM) and B.burgdorferi outer surface protein A lipoprotein(OspA-L) cooperatively with TLR2(PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein(oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL-or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion(PubMed:11441107, PubMed:20037584).
Ver Producto
Toll-Like Receptor 6 (TLR6) Antibody
TLR6 Antibody is a Rabbit Polyclonal Antibody against TLR6.
Ver Producto