Human Toll Like Receptor 6 (TLR6) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein TLR6
proveedor
Abbexareference
abx069371Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Toll Like Receptor 6 (TLR6) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Toll-like receptor 6 (TLR6) is a pattern-recognition receptor (PRR) in the toll-like receptor family that plays a critical role in the innate immune system. It is highly conserved across many species and primarily recognizes microbial components, particularly diacylated lipopeptides, which are lipid molecules derived from pathogens such as Gram-positive bacteria and certain fungi. TLR6 forms heterodimers with TLR2 to recognize these microbial products, allowing the immune system to detect the presence of pathogens and initiate a rapid immune response. TLR6 is expressed in various immune cells, including macrophages, dendritic cells, monocytes, neutrophils, and certain epithelial cells. Activation of TLR6 initiates downstream signaling cascades that promote the production of pro-inflammatory cytokines and chemokines, thereby coordinating immune responses and recruiting additional immune cells to the site of infection. This receptor also plays a role in tissue repair, and recent studies suggest its involvement in some chronic inflammatory and autoimmune diseases, as well as potential links to cancer. Understanding TLR6’s mechanisms and structure is essential for designing therapeutics that can modulate immune responses in a range of diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Toll Like Receptor 6 (TLR6)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 26.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Tyr608-Ser796 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TLR6
dry ice
No
availability
Shipped within 5-7 working days.
alias
Toll-like receptor 6,CD286
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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